From earlier studies it was known that Ectoin has the potential to prevent the induction of lung inflammation. In the recent issue of the European Respiratory Journal (Feb 2013; 41:433-442) the scientists describe that application of ectoine has also the ability to ameliorate ongoing lung inflammation. doi:10.1183/09031936.00132211
Chronic obstructive pulmonary disease (COPD) is one of the most frequent diseases in modern society. According to the World Health Organization (WHO), in 2007, 210 million people worldwide suffered from COPD. The main cause for COPD is the inhalation of air pollutants like tobacco smoke or particulate matter mainly coming from combustion processes. Effective anti-inflammatory therapies like the inhalation of glucocorticoids (cortisone) do not significantly improve the health status of the patients. The inflammatory reaction of the lung caused by the inhalation of pollutants is mostly dominated by a cell type (neutrophilic granulocytes) which is insensitive to this group of drugs.
Together with the company bitop AG, researchers at the Leibniz Research Institute of Environmental Medicine in Düsseldorf, Germany, investigated the effects of the extremolyte ectoine in a series of preclinical studies. Ectoin is a natural compound produced by bacteria which are able to survive under extreme conditions. The substance is known to stabilize cells and protect them against environmental stress.
“Exposure of the lungs to air pollution still poses a problem for the inhabitants of industrialised countries, leading to diseases like COPD with a high economic burden, and it is expected that this disease will be ranked as number three of death causing diseases within the next years. The local application of cell-protecting molecules like Ectoin is a possible new option in the treatment of COPD“ states Dr. Klaus Unfried at the IUF.
Researchers in the group of Dr. Unfried were able to demonstrate the cell-protecting capacity of Ectoin in a system of environmentally induced lung inflammation. From earlier studies it was known that Ectoin has the potential to prevent the induction of lung inflammation. In the recent issue of the well recognized European Respiratory Journal (Feb 2013; 41:433-442) the scientists describe that application of ectoine has also the ability to ameliorate ongoing lung inflammation. Together with members of the department of Traumatology and Hand Surgery and the department of Angiology, Pneumology and Cardiology of the University Clinics Düsseldorf, they were able to show that after exposure to pollutants the life span of the inflammatory cells is prolonged and thereby the inflammation is likely to be increased. The application of Ectoin in the lung prevents this enhancement of the inflammation. The biophysical stabilization of the cells reverts natural cell death to a level as it would occur without the effect of pollutants and, therefore, leads to a reduction of the inflammation. The relevance of this mechanism for humans was demonstrated using inflammatory cells isolated from the blood of COPD patients.
“Different studies with ectoine-containing products have shown good results in efficacy and safety in the treatment of allergic rhinitis or atopic dermatitis. An Ectoin containing inhalation solution has already shown first positive proof of concept results after application with patients suffering from mild asthma or pollutant induced lung inflammation. Based on the actual results from the IUF we are optimistic to further explore potential applications in humans " says Dr. Andreas Bilstein, Director at bitop AG.
Dr. Katharina Beyen | idw
Further reports about: > COPD > Ectoin > Environmental Medicine > IUF > Lung inflammation > Respiratory > air pollutant > anti-inflammatory therapies > chronic obstructive pulmonary disease > cortisone > environmental risk > inflammatory cells > inhalation of glucocorticoids > neutrophilic granulocytes
Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
20.10.2017 | Information Technology
20.10.2017 | Materials Sciences
20.10.2017 | Interdisciplinary Research