From earlier studies it was known that Ectoin has the potential to prevent the induction of lung inflammation. In the recent issue of the European Respiratory Journal (Feb 2013; 41:433-442) the scientists describe that application of ectoine has also the ability to ameliorate ongoing lung inflammation. doi:10.1183/09031936.00132211
Chronic obstructive pulmonary disease (COPD) is one of the most frequent diseases in modern society. According to the World Health Organization (WHO), in 2007, 210 million people worldwide suffered from COPD. The main cause for COPD is the inhalation of air pollutants like tobacco smoke or particulate matter mainly coming from combustion processes. Effective anti-inflammatory therapies like the inhalation of glucocorticoids (cortisone) do not significantly improve the health status of the patients. The inflammatory reaction of the lung caused by the inhalation of pollutants is mostly dominated by a cell type (neutrophilic granulocytes) which is insensitive to this group of drugs.
Together with the company bitop AG, researchers at the Leibniz Research Institute of Environmental Medicine in Düsseldorf, Germany, investigated the effects of the extremolyte ectoine in a series of preclinical studies. Ectoin is a natural compound produced by bacteria which are able to survive under extreme conditions. The substance is known to stabilize cells and protect them against environmental stress.
“Exposure of the lungs to air pollution still poses a problem for the inhabitants of industrialised countries, leading to diseases like COPD with a high economic burden, and it is expected that this disease will be ranked as number three of death causing diseases within the next years. The local application of cell-protecting molecules like Ectoin is a possible new option in the treatment of COPD“ states Dr. Klaus Unfried at the IUF.
Researchers in the group of Dr. Unfried were able to demonstrate the cell-protecting capacity of Ectoin in a system of environmentally induced lung inflammation. From earlier studies it was known that Ectoin has the potential to prevent the induction of lung inflammation. In the recent issue of the well recognized European Respiratory Journal (Feb 2013; 41:433-442) the scientists describe that application of ectoine has also the ability to ameliorate ongoing lung inflammation. Together with members of the department of Traumatology and Hand Surgery and the department of Angiology, Pneumology and Cardiology of the University Clinics Düsseldorf, they were able to show that after exposure to pollutants the life span of the inflammatory cells is prolonged and thereby the inflammation is likely to be increased. The application of Ectoin in the lung prevents this enhancement of the inflammation. The biophysical stabilization of the cells reverts natural cell death to a level as it would occur without the effect of pollutants and, therefore, leads to a reduction of the inflammation. The relevance of this mechanism for humans was demonstrated using inflammatory cells isolated from the blood of COPD patients.
“Different studies with ectoine-containing products have shown good results in efficacy and safety in the treatment of allergic rhinitis or atopic dermatitis. An Ectoin containing inhalation solution has already shown first positive proof of concept results after application with patients suffering from mild asthma or pollutant induced lung inflammation. Based on the actual results from the IUF we are optimistic to further explore potential applications in humans " says Dr. Andreas Bilstein, Director at bitop AG.
Dr. Katharina Beyen | idw
Further reports about: > COPD > Ectoin > Environmental Medicine > IUF > Lung inflammation > Respiratory > air pollutant > anti-inflammatory therapies > chronic obstructive pulmonary disease > cortisone > environmental risk > inflammatory cells > inhalation of glucocorticoids > neutrophilic granulocytes
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences