Prior studies by this multidisciplinary team of physician scientists at the Jonsson Cancer Center had shown that use of FDG PET/computed tomography (CT) could determine pathologic response after the first dose of chemotherapy drugs.
The researchers then wondered if the patients showing a significant PET response after the first round of chemotherapy also were surviving longer, said Dr. Fritz Eilber, an associate professor of surgical oncology, director of the Sarcoma Program at UCLA's Jonsson Cancer Center and senior author of the study.
"We did find that patients who experienced an early PET response to treatment had significantly increased survival," Eilber said. "This is vital because patients want to know if the drugs are working and what that says about their ultimate outcome."
The study was published April 1, 2012 in Clinical Cancer Research, a peer-reviewed journal of the American Association of Cancer Research.
In this study, 39 patients with soft tissue sarcoma underwent a PET scan to measure their tumor's metabolism, or how much glucose was being taken up by the tumor, prior to getting chemotherapy. The patients were given another PET scan after the first round of chemotherapy. Those whose tumors demonstrated a 25 percent or more decrease in metabolic activity – a response considered significant - were determined later to have significant increased survival rates compared to those patients who had less than a 25 percent decrease, Eilber said.
"It's an important finding because we can now identify whether patients are getting the right chemotherapy very quickly," Eilber said. "Patients don't want to have to wait until the cancer recurs or they die to find out whether their chemotherapy worked or not."
Going forward, Eilber and his team are working to design new molecular imaging tools that may tell them even more about a patient's cancer beyond the conventional FDG probe."Just looking at the size of the tumor is not good enough anymore," Eilber said. "We want to image what's happening within the tumor in real time."
UCLA's Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation's largest comprehensive cancer centers, the Jonsson center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2011, the Jonsson Cancer Center was named among the top 10 cancer centers nationwide by U.S. News & World Report, a ranking it has held for 11 of the last 12 years. For more information on the Jonsson Cancer Center, visit our website at http://www.cancer.ucla.edu
Kim Irwin | EurekAlert!
Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign
Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences