Prior studies by this multidisciplinary team of physician scientists at the Jonsson Cancer Center had shown that use of FDG PET/computed tomography (CT) could determine pathologic response after the first dose of chemotherapy drugs.
The researchers then wondered if the patients showing a significant PET response after the first round of chemotherapy also were surviving longer, said Dr. Fritz Eilber, an associate professor of surgical oncology, director of the Sarcoma Program at UCLA's Jonsson Cancer Center and senior author of the study.
"We did find that patients who experienced an early PET response to treatment had significantly increased survival," Eilber said. "This is vital because patients want to know if the drugs are working and what that says about their ultimate outcome."
The study was published April 1, 2012 in Clinical Cancer Research, a peer-reviewed journal of the American Association of Cancer Research.
In this study, 39 patients with soft tissue sarcoma underwent a PET scan to measure their tumor's metabolism, or how much glucose was being taken up by the tumor, prior to getting chemotherapy. The patients were given another PET scan after the first round of chemotherapy. Those whose tumors demonstrated a 25 percent or more decrease in metabolic activity – a response considered significant - were determined later to have significant increased survival rates compared to those patients who had less than a 25 percent decrease, Eilber said.
"It's an important finding because we can now identify whether patients are getting the right chemotherapy very quickly," Eilber said. "Patients don't want to have to wait until the cancer recurs or they die to find out whether their chemotherapy worked or not."
Going forward, Eilber and his team are working to design new molecular imaging tools that may tell them even more about a patient's cancer beyond the conventional FDG probe."Just looking at the size of the tumor is not good enough anymore," Eilber said. "We want to image what's happening within the tumor in real time."
UCLA's Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation's largest comprehensive cancer centers, the Jonsson center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2011, the Jonsson Cancer Center was named among the top 10 cancer centers nationwide by U.S. News & World Report, a ranking it has held for 11 of the last 12 years. For more information on the Jonsson Cancer Center, visit our website at http://www.cancer.ucla.edu
Kim Irwin | EurekAlert!
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences