Nutrition during the first days or weeks of life may have long-term consequences on health, potentially via a phenomenon known as the metabolic programming effect, according to a study to be presented Monday, May 2, at the Pediatric Academic Societies (PAS) annual meeting in Denver.
Metabolic programming is the concept that differences in nutritional experiences at critical periods early in life can program a person's metabolism and health for the future.
In this study, researchers compared growth, body composition and blood pressure in three groups of healthy, full-term newborns in the Neonatal Department of Hospices Civils de Lyon, Claude Bernard University, Lyon, France. One group received only breast milk for the first four months of life. The two other groups were randomized to receive either a low-protein formula with 1.8 grams of protein/100 kilocalories (g/kcal) or a high-protein formula with 2.7 g/100 kcal. The protein content of both formulas was within the recommended levels of 1.8 to 3 g/100 kcal.
After four months, the formula-fed infants continued to receive the same formula, and the breastfed infants were assigned to the low-protein formula, if needed.
Researchers, who followed 234 children for three years, found that exclusive breastfeeding during the first weeks of life induced a specific pattern of growth and a specific metabolic profile, which appeared to differ in formula-fed infants. The protein content in infant formula may be a key factor in inducing these differences, according to study co-author Guy Putet, MD.
As early as 15 days of life, blood insulin levels were lower in breastfed infants than in formula-fed infants. These differences persisted at 4 months of age, but no differences were seen at 9 months.
Growth patterns also were different between groups during the first year of life, but by 3 years of age, there no longer was any difference in length, weight or body composition (fat mass, lean body mass) between groups. The exception was head circumference, which was slightly lower in the low-protein formula group but still well within the normal range.
At 3 years, an unexpected result was that diastolic and mean blood pressures were higher in the infants who had been fed the high-protein formula compared to the breastfed infants, Dr. Putet noted. However, these levels were still within the normal range.
"It appears that formula feeding induces differences in some hormonal profiles as well as in patterns of growth compared with breastfeeding," Dr. Putet said. "The long-term consequences of such changes are not well-understood in humans and may play a role in later health. Well-designed studies with long-term follow-up are needed."
If breastfeeding is not possible, Dr. Putet concluded, infants should be fed formulas that allow a growth pattern and a metabolic profile similar to that of breastfed infants.
To view the abstract, go to http://www.abstracts2view.com/pas/view.php?nu=PAS11L1_925.
The Pediatric Academic Societies (PAS) are four individual pediatric organizations who co-sponsor the PAS Annual Meeting – the American Pediatric Society, the Society for Pediatric Research, the Academic Pediatric Association, and the American Academy of Pediatrics. Members of these organizations are pediatricians and other health care providers who are practicing in the research, academic and clinical arenas. The four sponsoring organizations are leaders in the advancement of pediatric research and child advocacy within pediatrics, and all share a common mission of fostering the health and well being of children worldwide. For more information, visit www.pas-meeting.org. Follow news of the PAS meeting on Twitter at http://twitter.com/PedAcadSoc.
Susan Martin | EurekAlert!
Cystic fibrosis alters the structure of mucus in airways
28.06.2017 | University of Iowa Health Care
Mice provide insight into genetics of autism spectrum disorders
28.06.2017 | University of California - Davis
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
28.06.2017 | Physics and Astronomy
28.06.2017 | Physics and Astronomy
28.06.2017 | Health and Medicine