Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early nutrition has a long-term metabolic impact

02.05.2011
Growth, hormonal profiles differ between breastfed, formula-fed infants

Nutrition during the first days or weeks of life may have long-term consequences on health, potentially via a phenomenon known as the metabolic programming effect, according to a study to be presented Monday, May 2, at the Pediatric Academic Societies (PAS) annual meeting in Denver.

Metabolic programming is the concept that differences in nutritional experiences at critical periods early in life can program a person's metabolism and health for the future.

In this study, researchers compared growth, body composition and blood pressure in three groups of healthy, full-term newborns in the Neonatal Department of Hospices Civils de Lyon, Claude Bernard University, Lyon, France. One group received only breast milk for the first four months of life. The two other groups were randomized to receive either a low-protein formula with 1.8 grams of protein/100 kilocalories (g/kcal) or a high-protein formula with 2.7 g/100 kcal. The protein content of both formulas was within the recommended levels of 1.8 to 3 g/100 kcal.

After four months, the formula-fed infants continued to receive the same formula, and the breastfed infants were assigned to the low-protein formula, if needed.

Researchers, who followed 234 children for three years, found that exclusive breastfeeding during the first weeks of life induced a specific pattern of growth and a specific metabolic profile, which appeared to differ in formula-fed infants. The protein content in infant formula may be a key factor in inducing these differences, according to study co-author Guy Putet, MD.

As early as 15 days of life, blood insulin levels were lower in breastfed infants than in formula-fed infants. These differences persisted at 4 months of age, but no differences were seen at 9 months.

Growth patterns also were different between groups during the first year of life, but by 3 years of age, there no longer was any difference in length, weight or body composition (fat mass, lean body mass) between groups. The exception was head circumference, which was slightly lower in the low-protein formula group but still well within the normal range.

At 3 years, an unexpected result was that diastolic and mean blood pressures were higher in the infants who had been fed the high-protein formula compared to the breastfed infants, Dr. Putet noted. However, these levels were still within the normal range.

"It appears that formula feeding induces differences in some hormonal profiles as well as in patterns of growth compared with breastfeeding," Dr. Putet said. "The long-term consequences of such changes are not well-understood in humans and may play a role in later health. Well-designed studies with long-term follow-up are needed."

If breastfeeding is not possible, Dr. Putet concluded, infants should be fed formulas that allow a growth pattern and a metabolic profile similar to that of breastfed infants.

To view the abstract, go to http://www.abstracts2view.com/pas/view.php?nu=PAS11L1_925.

The Pediatric Academic Societies (PAS) are four individual pediatric organizations who co-sponsor the PAS Annual Meeting – the American Pediatric Society, the Society for Pediatric Research, the Academic Pediatric Association, and the American Academy of Pediatrics. Members of these organizations are pediatricians and other health care providers who are practicing in the research, academic and clinical arenas. The four sponsoring organizations are leaders in the advancement of pediatric research and child advocacy within pediatrics, and all share a common mission of fostering the health and well being of children worldwide. For more information, visit www.pas-meeting.org. Follow news of the PAS meeting on Twitter at http://twitter.com/PedAcadSoc.

Susan Martin | EurekAlert!
Further information:
http://www.aap.org

Further reports about: PAS Pediatric academic blood pressure body composition formula-fed infants societies

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>