Organs can become significantly damaged during transplantation, but a new article published in the BJS (British Journal of Surgery) offers a protective strategy that could keep them safe and allow them to function optimally after the procedure.
When an organ is transplanted from a donor to a recipient, there is a period of time when the organ is deprived of normal blood flow. While this in itself can cause tissue damage, additional damage may also occur when blood flow is restored to the organ due to a high risk of blood clotting.
Investigators led by Thierry Hauet, MD, PhD, of the Institut National de la Santé et de la Recherche Médicale (INSERM), the University of Poitiers, and the Centre Hospitalier Universitaire (CHU) de Poitiers, in France, wondered whether anticoagulants or "blood thinners" might help protect transplant organs against these effects. The team tested the potential of fondaparinux in an experimental model of kidney transplantation. Use of the anticoagulant was linked with improved kidney function both immediately after transplantation and several months later.
"People die every day from the lack of available organs. This study demonstrates the benefits of anticoagulation therapy using new and original drugs at the time of organ collection," said Dr. Hauet. "Such therapy could augment the pool of available organs and allow for the safe use of marginal organs, which have characteristics associated with poorer outcomes or come from donors with medical complexities."
Such an anticoagulation strategy could be an important addition to current transplant protocols to limit tissue damage and improve outcomes in patients receiving kidney, liver, pancreas, lung, heart, and other organ transplants.
This study is published in BJS. Media wishing to receive a PDF of this article may contact email@example.com.
Full citation: Article: "Kidney graft outcome using an anti-Xa therapeutic strategy in an experimental model of severe ischaemia-reperfusion injury." S. Tillet, S. Giraud, P. O. Delpech, R. Thuillier, V. Ameteau, J. M. Goujon, B. Renelier, L. Macchi, T. Hauet, and G. Mauco. Br J Surg; Published Online: November 17, 2014 (DOI: 10.1002/bjs.9662)
URL Upon Publication: http://doi.wiley.com/10.1002/bjs.9662
Author Contact: To arrange an interview please contact, Mr Didier Dubrana at firstname.lastname@example.org; Mr Stephan Maret at email@example.com; or Mme Marion Sabourin at firstname.lastname@example.org.
About the Journal:
BJS is the premier peer-reviewed surgical journal in Europe and one of the top surgical periodicals in the world. Its international readership is reflected in its prestigious international Editorial Board, supported by a panel of over 1200 reviewers worldwide. BJS features the very best in clinical and laboratory-based research on all aspects of general surgery and related topics and has a tradition of publishing high quality papers in breast, upper GI, lower GI, vascular, endocrine and surgical sciences. Papers include leading articles, reviews and original research articles, correspondence and book reviews. The journal celebrated its centennial year in 2013. The current impact factor is 5.21. Visit http://www.bjs.co.uk for more information.
Wiley is a global provider of content-enabled solutions that improve outcomes in research, education, and professional practice. Our core businesses produce scientific, technical, medical, and scholarly journals, reference works, books, database services, and advertising; professional books, subscription products, certification and training services and online applications; and education content and services including integrated online teaching and learning resources for undergraduate and graduate students and lifelong learners.
Founded in 1807, John Wiley & Sons, Inc. (NYSE: JWa, JWb), has been a valued source of information and understanding for more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Wiley and its acquired companies have published the works of more than 450 Nobel laureates in all categories: Literature, Economics, Physiology or Medicine, Physics, Chemistry, and Peace. Wiley's global headquarters are located in Hoboken, New Jersey, with operations in the U.S., Europe, Asia, Canada, and Australia. The Company's website can be accessed at http://www.wiley.com
Evelyn Martinez | EurekAlert!
Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital
New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
11.12.2017 | Information Technology
11.12.2017 | Power and Electrical Engineering
11.12.2017 | Event News