Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Drug tracked in tissue

17.10.2011
When a new drug is developed, the manufacturer must be able to show that it reaches its intended goal in the body’s tissue, and only that goal. Such studies could be made easier with a new method now established at Lund University in Sweden.

The method is a special type of mass spectrometry which can be used on drugs ‘off the shelf’, i.e. without any radioactive labelling which may change the behaviour of the drug. With this method, researchers György Marko-Varga and Thomas Fehniger have managed to create a molecular image of the drug in the tissue.

The tissue examined comes from biopsies from the lungs of patients with lung cancer and chronic obstructive lung disease (COPD), who have inhaled a drug to dilate the airways. The examination showed the precise spatial distribution of the drug within the tissue. The results are based on an analysis of 3 000 measurement points of 0.01 mm2 in each biopsy sample.

“When you want to register a new drug, you must be able to both explain its exact mechanisms of action and show that it is effective and safe. In order to avoid side-effects, the drug should reach only the cells for which it is intended. Our new technical platform makes it easier to show this”, says György Marko-Varga.

He believes it will be possible to use the new technology to develop safer and more effective drug candidates. In the future it could also be used in clinical treatment, to help doctors select the right drug for a specific patient.

The researchers first conducted animal experiments, using drug doses 100 times higher than those now measured in patients. The group then optimised and refined the technology to achieve the sensitivity needed for measuring doses of drugs normally administered to patients.

Professors György Marko-Varga and Thomas Fehniger are both members of the Department of Measurement Technology and Industrial Electrical Engineering in Lund. Thomas Fehniger (who is the principal author of the article) is currently working at The Tallinn University of Technology, sponsored by the Estonian Science Foundation under the European Social Fund, while György Marko-Varga works part time for the University of Tokyo. The two researchers have previously worked at the pharmaceuticals company AstraZeneca, which has also contributed to the study. The study was recently published in the journal Analytical Chemistry.

Contact:
Thomas Fehniger: +46 738 328012, thomas.fehniger@telia.com
György Marko-Varga: +46 46 222 37 21, +46 703 567080, Gyorgy.Marko-Varga@elmat.lth.se

Megan Grindlay | idw
Further information:
http://pubs.acs.org/doi/abs/10.1021/ac2014349
http://pubs.acs.org/cen/news/89/i41/8941scene.html

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Researchers release the brakes on the immune system

18.10.2017 | Health and Medicine

Separating methane and CO2 will become more efficient

18.10.2017 | Life Sciences

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>