However, some patients are unable to effectively reduce their low-density lipoprotein cholesterol (LDL cholesterol) or "bad cholesterol" levels with statins, the most commonly used medication to treat high cholesterol, due to their bodies' inability to tolerate or sufficiently respond to the medicine.
Now researchers at Brigham and Women's Hospital have shown that in patients already on a statin, the addition of a new drug, called AMG 145, can reduce LDL cholesterol levels by up to 66 percent after 12 weeks.The study was presented at the 2012 American Heart Association Scientific Sessions and electronically published in Lancet on November 6, 2012.
In participants who received AMG 145 every two weeks, the drug reduced LDL cholesterol in a dose-dependent manner by 42 to 66 percent at the end of twelve weeks compared to placebo.For those taking AMG 145 every four weeks, the drug reduced LDL cholesterol in a dose-dependent manner by 42 to 50 percent at the end of twelve weeks compared to placebo. Moreover, just one week after a dose, researchers saw LDL cholesterol reduced by up to 85 percent.
Marjorie Montemayor-Quellenberg | EurekAlert!
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