Twelve percent of adults in Sweden have diseases related to their use of medicines. But in four cases of ten it would have been possible to avoid the undesired effects. These are the conclusions of a thesis presented at the Sahlgrenska Academy, University of Gothenburg.
Katja Hakkarainen and her research colleagues have used 7,099 questionnaires and 4,970 patient medical records in Östergötland to map drug-related morbidity. Their work has included side effects, toxicity, the development of drug dependence, the insufficient effect of drugs, and lack of drug treatment.
The study is described in Katja Hakkarainen’s thesis, and shows that 19% of all adults in Sweden report some form of drug-related morbidity, while examination of the medical records gives a figure of 12%.
Two effects were most commonly reported: side effects, and insufficient effect of the drug.
Could have been prevented
At the same time, 20% of those who completed the questionnaire stated that they themselves, healthcare personnel or relatives could have prevented these effects.
Clinical experts who have examined the drug-related morbidity described in the medical records also came to the conclusion that 39%, or four cases of ten, could have been prevented.
“Our results show that drug-related morbidity is a significant public health problem, and that it must be prevented across the whole of the healthcare sector,” says Katja Hakkarainen, pharmacist and researcher at the Sahlgrenska Academy, University of Gothenburg.
Most previous studies in the field have focused on side effects associated with drug use. Katja Hakkarainen’s thesis, in contrast, draws attention to a broader spectrum of drug-related morbidity, including insufficient effects of medicines. The latter effect means, for example, that a potentially active drug has been taken at the wrong dose by the patient, or that it has been prescribed or used wrongly in some other way.
“The studies show that both those treating outpatients and those treating inpatients must become better at recognising drug-related morbidity. Further, new studies should be carried out by scientists, experts in safety and healthcare personnel together to develop preventative strategies,” says Katja Hakkarainen.
The questionnaire study was carried out in 2010, and the medical records were reviewed for year 2008, in collaboration with the Nordic School of Public Health NHV and Linköping University.
The thesis Prevalence and nature of adverse drug events and the potential for their prevention – Population-based studies among adults was successfully defended at a disputation on 21 March, 2014.
Link to the thesis: https://gupea.ub.gu.se/handle/2077/34825
Katja Hakkarainen, pharmacist and research student at the Sahlgrenska Academy, University of Gothenburg
+46 (0)31 693989
Krister Svahn | idw - Informationsdienst Wissenschaft
Real-time imaging of lung lesions during surgery helps localize tumors and improve precision
30.07.2015 | American Association for Thoracic Surgery
Experimental MERS vaccine shows promise in animal studies
29.07.2015 | NIH/National Institute of Allergy and Infectious Diseases
Physicists from Regensburg and Marburg, Germany have succeeded in taking a slow-motion movie of speeding electrons in a solid driven by a strong light wave. In the process, they have unraveled a novel quantum phenomenon, which will be reported in the forthcoming edition of Nature.
The advent of ever faster electronics featuring clock rates up to the multiple-gigahertz range has revolutionized our day-to-day life. Researchers and...
Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.
Joint BioEnergy Institute study identifies bacterial protein that is key to protecting rice against bacterial blight
A bacterial signal that when recognized by rice plants enables the plants to resist a devastating blight disease has been identified by a multi-national team...
Researchers in the Cockrell School of Engineering at The University of Texas at Austin are one step closer to delivering smart windows with a new level of energy efficiency, engineering materials that allow windows to reveal light without transferring heat and, conversely, to block light while allowing heat transmission, as described in two new research papers.
By allowing indoor occupants to more precisely control the energy and sunlight passing through a window, the new materials could significantly reduce costs for...
Argonne scientists used Mira to identify and improve a new mechanism for eliminating friction, which fed into the development of a hybrid material that exhibited superlubricity at the macroscale for the first time. Argonne Leadership Computing Facility (ALCF) researchers helped enable the groundbreaking simulations by overcoming a performance bottleneck that doubled the speed of the team's code.
While reviewing the simulation results of a promising new lubricant material, Argonne researcher Sanket Deshmukh stumbled upon a phenomenon that had never been...
23.07.2015 | Event News
10.07.2015 | Event News
25.06.2015 | Event News
30.07.2015 | Life Sciences
30.07.2015 | Trade Fair News
30.07.2015 | Awards Funding