In a subsequent pharmacological study with one of the identified compounds, the scientists found a drug-induced reduction of aversive memory. This could have implications for the treatment of posttraumatic stress disorder, which is characterized by intrusive traumatic memories. The findings have been published in the latest edition of the magazine PNAS.
Genome-based identification of drugs.
Image: University of Basel
In the last decade, the human genome project has led to an unprecedented rate of discovery of genes related to humane disease. However, so far it has not been clear to what extent this knowledge can be used for the identification of new drugs, especially in the field of neuropsychiatric disorders. The research groups of Prof. Andreas Papassotiropoulos and Prof. Dominique de Quervain of the Psychiatric University Clinics, the Department of Psychology and the Biozentrum of the University of Basel performed a multinational collaborative study, in order to analyze the genetic basis of emotionally aversive memory – a trait central to anxiety disorders such as posttraumatic stress disorder. In a gene-set analysis the scientists identified 20 potential drug target genes that are involved in the process of remembering negative events.Known Antihistamine shows Effect
With this study, the scientists were for the first time able to demonstrate that human genome information can be used to identify substances that can modulate memory. «The rapid development of innovative methods for genetic analysis has made this new and promising approach possible», says Papassotiropoulos. The scientists are now planning subsequent studies: «In a further step, we will try to identify and develop memory enhancing drugs», explains de Quervain. The scientists hope to provide new input for the development of urgently needed improved drugs for the treatment of neuropsychiatric diseases.Company for clinical Applications
Prof. Dr. Dominique de Quervain, Tel. +41 61 267 02 37, Email: firstname.lastname@example.org
Christoph Dieffenbacher | Universität Basel
Indian roadside refuse fires produce toxic rainbow
26.10.2016 | Duke University
Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
26.10.2016 | Materials Sciences
26.10.2016 | Health and Medicine
26.10.2016 | Physics and Astronomy