Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Drug reduces negative Memory

22.10.2013
Through analysis of the human genome, Basle scientists have identified molecules and compounds that are related to human memory.

In a subsequent pharmacological study with one of the identified compounds, the scientists found a drug-induced reduction of aversive memory. This could have implications for the treatment of posttraumatic stress disorder, which is characterized by intrusive traumatic memories. The findings have been published in the latest edition of the magazine PNAS.


Genome-based identification of drugs.
Image: University of Basel

In the last decade, the human genome project has led to an unprecedented rate of discovery of genes related to humane disease. However, so far it has not been clear to what extent this knowledge can be used for the identification of new drugs, especially in the field of neuropsychiatric disorders. The research groups of Prof. Andreas Papassotiropoulos and Prof. Dominique de Quervain of the Psychiatric University Clinics, the Department of Psychology and the Biozentrum of the University of Basel performed a multinational collaborative study, in order to analyze the genetic basis of emotionally aversive memory – a trait central to anxiety disorders such as posttraumatic stress disorder. In a gene-set analysis the scientists identified 20 potential drug target genes that are involved in the process of remembering negative events.

Known Antihistamine shows Effect
In a double-blind, placebo-controlled study and based on the results of the genetic analysis, the scientists examined a compound that interacts with one of the previously identified gene products. Surprisingly, the said compound is a known antihistamine. A single dose of the drug led to significant reduction of memory recall of previously seen aversive pictures; however, it did not affect memory of neutral or positive pictures. These findings could have implications for the treatment of posttraumatic stress disorder.

With this study, the scientists were for the first time able to demonstrate that human genome information can be used to identify substances that can modulate memory. «The rapid development of innovative methods for genetic analysis has made this new and promising approach possible», says Papassotiropoulos. The scientists are now planning subsequent studies: «In a further step, we will try to identify and develop memory enhancing drugs», explains de Quervain. The scientists hope to provide new input for the development of urgently needed improved drugs for the treatment of neuropsychiatric diseases.

Company for clinical Applications
In order to bring their findings to clinical application, de Quervain and Papassotiropulos founded the company GeneGuide Ltd. this year. The company has specialized in the human genome-based research approach and the discovery of new drugs for neuropsychiatric diseases. This novel approach has been met with great interest by the pharmaceutical industry, since so far the development of improved neuropsychiatric drugs has been rather disappointing.
Original Citation
Andreas Papassotiropoulos, Christiane Gerhards, Angela Heckc, Sandra Ackermann, Amanda Aerni, Nathalie Schicktanz, Bianca Auschra, Philippe Demougin, Eva Mumme, Thomas Elbert, Verena Ertl, Leo Gschwind, Edveena Hanser, Kim-Dung Huynh, Frank Jessen, Iris-Tatjana Kolassa, Annette Milnik, Paolo Paganetti, Klara Spalek, Christian Vogler, Andreas Muhs, Andrea Pfeifer, and Dominique J.-F. de Quervain
Human genome-guided identification of memory-modulating drugs
PNAS 2013; published ahead of print October 21, 2013 | doi: 10.1073/pnas.1314478110
Further Information
Prof. Dr. Andreas Papassotiropoulos, Tel. +41 61 267 05 99, Email: andreas.papas@unibas.ch

Prof. Dr. Dominique de Quervain, Tel. +41 61 267 02 37, Email: dominique.dequervain@unibas.ch

Christoph Dieffenbacher | Universität Basel
Further information:
http://www.unibas.ch
http://www.pnas.org/content/early/2013/10/16/1314478110

More articles from Health and Medicine:

nachricht 'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS

nachricht New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>