Researchers at Uppsala University and Uppsala University Hospital have identified a protein in the lungs that is important to the immune defense system in an autoimmune lung disorder that is not seldom fatal. The newly discovered protein, called KCNRG, occurs in cells in the lower air ways found on the surface of the bronchia.
This observation enables researchers to study more closely the first phase of the autoimmune disease, that is, when the immune system erroneously attacks the body's own tissues instead of attacking foreign organisms like bacteria or viruses. The discovery also provides new avenues for developing new diagnostic methods.
The researchers used an unusual hereditary autoimmune disorder, autoimmune polyendocrine syndrome type 1 (APS-1), as a model. Patients with this disease are afflicted by the immune system erroneously attacking several tissues, such as the liver, insulin-producing cells, and adrenal glands.
"Only now have we understood that the lungs are attacked as well and that in many cases this is the most serious component of the disease APS-1," says Dr. Mohammad Alimohammadi.
"It's our hope that the discovery of the protein that the immune system targets, besides making early diagnosis possible, will also be possible to use in understanding the mechanism behind the occurrence of common public health disorders like asthma and chronic bronchitis."
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Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
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Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.
From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...
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