Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New discoveries linking gut bacteria with cholesterol metabolism give hope for the future

18.02.2013
Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, show that cholesterol metabolism is regulated by bacteria in the small intestine. These findings may be important for the development of new drugs for cardiovascular disease.

It is well established that cholesterol is the major risk factor for cardiovascular disease. Cholesterol – which is mainly synthesized in the body but also obtained from dietary sources – is converted to bile acids in the liver, which are then secreted into the intestine and either removed from the body or recycled back to the liver.

The influence of gut bacteria on human health and disease is a rapidly expanding research area. Fredrick Bäckhed’s research group is a leader in this field and is investigating how gut bacteria are linked to lifestyle diseases such as obesity, diabetes and cardiovascular disease.

In a study published in the prestigious journal Cell Metabolism, they show that gut bacteria reduce bile acid synthesis in the liver by signaling through a specific protein, known as the FXR receptor, in the small intestine.

‘Drugs that reduce cholesterol levels have, in recent years, greatly reduced deaths from cardiovascular disease. Our study is a step forward because we have shown how gut bacteria regulate the formation of bile acids from cholesterol’, says Sama Sayin, medical doctor and PhD student at the Sahlgrenska Academy, University of Gothenburg, and the study's first author.

The FXR receptor not only affects cholesterol metabolism but is also involved in the body's sugar and fat metabolism.

‘If future research can identify the specific bacteria that affect FXR signaling in the gut, this could lead to new ways to treat diabetes and cardiovascular disease’, says Fredrik Bäckhed, professor at the Sahlgrenska Academy, University of Gothenburg, who led the study.

The article ‘Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-betamuricholic acid, a naturally occurring FXR antagonist’ is published in Cell Metabolism on February 5. The study is a collaboration with researchers from VTT in Finland, the Karolinska Institute and AstraZeneca in Mölndal.

The Wallenberg Laboratory: http://www.wlab.gu.se/

Contact:
Fredrick Bäckhed, professor at the Sahlgrenska Academy, University of Gothenburg, and director of the Wallenberg Laboratory, University of Gothenburg
+ 46 (0) 31-342 7833
+ 46 (0) 70-2182355
fredrik.backhed@wlab.gu.se
Sama Sayin, PhD student at the Wallenberg Laboratory and Department of Molecular and Clinical Medicine, University of Gothenburg
+ 46 (0) 31-342 8672
+ 46 (0) 73-1541051
sama.sayin@wlab.gu.se

Annika Koldenius | idw
Further information:
http://www.gu.se
http://www.wlab.gu.se/

More articles from Health and Medicine:

nachricht 'Exciting' discovery on path to develop new type of vaccine to treat global viruses
18.09.2017 | University of Southampton

nachricht A new approach to high insulin levels
18.09.2017 | Schweizerischer Nationalfonds SNF

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

Im Focus: Silencing bacteria

HZI researchers pave the way for new agents that render hospital pathogens mute

Pathogenic bacteria are becoming resistant to common antibiotics to an ever increasing degree. One of the most difficult germs is Pseudomonas aeruginosa, a...

Im Focus: Artificial Enzymes for Hydrogen Conversion

Scientists from the MPI for Chemical Energy Conversion report in the first issue of the new journal JOULE.

Cell Press has just released the first issue of Joule, a new journal dedicated to sustainable energy research. In this issue James Birrell, Olaf Rüdiger,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

New quantum phenomena in graphene superlattices

19.09.2017 | Physics and Astronomy

A simple additive to improve film quality

19.09.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>