Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Differences in cell response could explain higher rates of hypertension in African-Americans

30.08.2011
A key difference in the way that cells from African-Americans respond to inflammation could be an answer to why this group is disproportionately affected by hypertension, something that has eluded scientists for many years.

In a study published this month in Vascular Health and Risk Management, lead author Michael Brown and his team tested the effects of TNF-Ü, a protein that causes inflammation when cells are damaged, on endothelial cells – which line blood vessels – in both African-Americans and Caucasians, to determine whether the inflammation affected the cells differently.

Among African-American cells, there was a nearly 90 percent increase in the production of endothelial microparticles, small vesicles that are released during inflammation. Individuals with hypertension have been shown to have higher levels of these microparticles in their bloodstream. Among Caucasians, there was only an eight percent increase in their production.

Brown said that although follow-up research needed to be done, "it appears that the endothelial cells in African Americans are more susceptible to the damaging effects of this inflammation." Brown is the director of the Hypertension Molecular and Applied Physiology Laboratory at Temple's College of Health Professions and Social Work.

Brown's research is unique in that it focuses on studying risk of hypertension at the cellular level; most research focuses on the clinical or physiological aspect. For more than 10 years, Brown has been trying to unlock the genetic reason behind the higher rates of hypertension and cardiovascular disease among African Americans.

Brown's research includes an exercise component, to test whether physical activity can reverse or prevent the damage done by hypertension at the cellular level.

"In our human study we have pre-hypertensive African-Americans, and we find this level of endothelial impairment. Knowing so early how inflammation can affect cells means we can be at a place to intervene before they go on to develop hypertension," said Brown. "That intervention could be lifestyle modification, diet and exercise to improve vascular health."

Other authors on this study are Deborah Feairheller, Sunny Thakkar, Praveen Veerabhadrappa and Joon-Young Park of the department of kinesiology. Funding for this study was provided by the National Heart Lung and Blood Institute at the National Institutes of Health.

Renee Cree | EurekAlert!
Further information:
http://www.temple.edu

More articles from Health and Medicine:

nachricht 'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS

nachricht New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Japanese researchers develop ultrathin, highly elastic skin display

19.02.2018 | Information Technology

Dispersal of Fish Eggs by Water Birds – Just a Myth?

19.02.2018 | Ecology, The Environment and Conservation

Studying mitosis' structure to understand the inside of cancer cells

19.02.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>