Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Diet may regulate obesity health risks, but genes decide

02.12.2008
The risk of obese people developing the metabolic syndrome that leads to diabetes, hypertension, and heart disease, can not be solved by a one-size-fits-all diet programme, according to new scientific findings.

The results of Lipgene, a five year EU research programme, show that personalised nutrition diets based on peoples genetic make-up will be the way of the future when tackling obesity and its associated health risks.

Currently, obesity costs the EU an estimated €32.8 billion each year. And, at current rates, it is estimated that 50% of Europeans will be obese by 2050.

Obesity results when excess calories are consumed and insufficient energy is spent (physical inactivity). Obesity is a major health hazard worldwide, it is directly linked to several common diseases such as diabetes, hypertension, heart disease, and some cancers.

“We analysed the findings from 500 volunteers across Europe who took part in a dietary programme to measure the effects of different diets on the development of the metabolic syndrome associated with obesity,” says Professor Helen Roche from the Institute of Food and Health at University College Dublin, one of the principal scientists on the Lipgene programme.

“The volunteers, each of whom were previously identified as obese and at risk from developing associated health complications, were placed on one of four specific diets,” Professor Roche explains.

One was high fat, high in saturated fats, like the average Irish diet. One was high fat, high in monounsaturated fats, like the average Mediterranean diet. And two were low fat diets one of which had a fish oil supplement.

“After the dietary programme was complete the volunteers were tested for reductions in any of the five main factors associated with the metabolic syndrome - high blood glucose; high levels of fats in the blood; high blood pressure; a waist circumference greater than 100cm; and low levels of good cholesterol (HDL).”

“The findings show that different fats have different health effects. A high saturated fat diet dis-improved the metabolic profile of subjects whilst the fish oils had positive effects. But certain clusters of genes determined a volunteer’s responsiveness to dietary interventions. Some of the volunteers experienced obvious positive effects while others experienced little or no changes to the metabolic syndrome indicators,” says Professor Roche.

As the common genetic variations, or polymorphisms, identified in the volunteer group are carried in 25% - 30% of the general population, the sample is clinically relevant, according to the scientists. The findings will now be tested against different population cohorts in Ireland and elsewhere in Europe.

If the results are confirmed by further studies, we will see the creation of more effective dietary treatments and nutritional therapies for obesity. Into the future, a GP is likely to take a blood sample from a patient to compare their genotype against genes active in common diseases and related this to the person’s lifestyle and environmental factors to gauge whether physical activity as opposed to nutritional regulation might work better for each individual patient.

It may be like visiting a GP to be measured for a certain health fitting which has been proven to work for your genetic type - just as we visit tailors and dress makers for fitted suits and dresses that make us feel and look better.

Professor Michael Gibney from University College Dublin, the coordinator of the Lipgene project has called on EU policy makers to evaluate the evidence presented by the EU Lipgene project with a view to improving the health of the EU population.

Dominic Martella | alfa
Further information:
http://www.ucd.ie

More articles from Health and Medicine:

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Previous evidence of water on mars now identified as grainflows

21.11.2017 | Physics and Astronomy

NASA's James Webb Space Telescope completes final cryogenic testing

21.11.2017 | Physics and Astronomy

New catalyst controls activation of a carbon-hydrogen bond

21.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>