“The majority of diabetics will over time develop severe or fatal complications, but 10–15 per cent never do. They are the ones we are interested in in the PROLONG study”, explains Valeriya Lyssenko, who along with Peter Nilsson, both from Lund University Diabetes Centre, in Sweden, leads the PROLONG study.
The risk of dying from cardiovascular disease is two to three times higher for diabetics than for non-diabetics. The small blood vessels are also damaged. After only ten years with diabetes, 70 per cent of patients will have some form of kidney damage that may progress to kidney failure. As many suffer from eye complications – some will develop severe visual impairment and two per cent will become blind.
“The blood vessels and other organs of the body become sugar coated and stiff. It is reminiscent of premature biological ageing”, says Peter Nilsson.Half of the veterans
Today there are approximately 12 000 people in Sweden who have had diabetes for more than 30 years; of these, 1 600 have had it for over 50 years.
“About half of these diabetic veterans do not have major complications. Two thirds of those who have had diabetes for more than 50 years have escaped complications. Clearly they are different and we want to find out what it is that protects them”, says Valeriya Lyssenko.Greatest risk passed after 30 years
The 30-year limit has been chosen because a person who has had diabetes for such a long time without developing complications is unlikely to do so later in life.Copying nature’s protective mechanisms
“If we can identify factors protecting these veterans from devastating complications, then it might be possible to develop drugs that can do the same thing”, says Valeriya Lyssenko.
“I have dreamt of performing a study like this for a long time”, adds Peter Nilsson.
PROLONG stands for PROtective genes in diabetes and LONGevity
Major diabetic complications include kidney disease (nephropathy), eye damage (retinopathy), heart attacks and stroke.For more information:
Megan Grindlay | idw
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
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19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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