Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Why do some diabetics escape complications?

21.01.2011
Much research has been carried out on why diabetics develop complications. Now researchers are asking the question the other way around. They want to know why some diabetic patients do not develop complications. What is it that protects them? The PROLONG study could provide the answer.

“The majority of diabetics will over time develop severe or fatal complications, but 10–15 per cent never do. They are the ones we are interested in in the PROLONG study”, explains Valeriya Lyssenko, who along with Peter Nilsson, both from Lund University Diabetes Centre, in Sweden, leads the PROLONG study.

Stiff sugary arteries
Despite decades of intensive research on diabetes complications, the fundamental mechanisms are not yet fully known. Neither is it possible to prevent or treat the damage to the blood vessels that affects the majority of diabetics.

The risk of dying from cardiovascular disease is two to three times higher for diabetics than for non-diabetics. The small blood vessels are also damaged. After only ten years with diabetes, 70 per cent of patients will have some form of kidney damage that may progress to kidney failure. As many suffer from eye complications – some will develop severe visual impairment and two per cent will become blind.

“The blood vessels and other organs of the body become sugar coated and stiff. It is reminiscent of premature biological ageing”, says Peter Nilsson.

Half of the veterans
Perhaps nature itself can answer the question of why some patients are protected. This is what the PROLONG study will investigate.

Today there are approximately 12 000 people in Sweden who have had diabetes for more than 30 years; of these, 1 600 have had it for over 50 years.

“About half of these diabetic veterans do not have major complications. Two thirds of those who have had diabetes for more than 50 years have escaped complications. Clearly they are different and we want to find out what it is that protects them”, says Valeriya Lyssenko.

Greatest risk passed after 30 years
The PROLONG study is starting now in Skåne with a pilot study of patients with diabetes duration of more than 30 years. At a later stage patients will be recruited from all hospitals and health care centres in Sweden. They will be compared with diabetics who have already developed severe complications despite having had diabetes for less than 15 years.

The 30-year limit has been chosen because a person who has had diabetes for such a long time without developing complications is unlikely to do so later in life.

Copying nature’s protective mechanisms
Participants in the PROLONG study will answer questions about their lifestyle and about diseases they, or their closest relatives, may have. Various blood samples, including genetic tests, will be analysed, and close relatives of the participants will also be invited to take part in the study.

“If we can identify factors protecting these veterans from devastating complications, then it might be possible to develop drugs that can do the same thing”, says Valeriya Lyssenko.

“I have dreamt of performing a study like this for a long time”, adds Peter Nilsson.

PROLONG stands for PROtective genes in diabetes and LONGevity

Major diabetic complications include kidney disease (nephropathy), eye damage (retinopathy), heart attacks and stroke.

For more information:
Valeriya Lyssenko, +46 40 39 12 14, +46 730 42 73 52
Valeriya.Lyssenko@med.lu.se
Peter Nilsson, +46 40 33 24 15, +46 704 50 34 56
Peter.Nilsson@med.lu.se

Megan Grindlay | idw
Further information:
http://www.lu.se

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

High-precision magnetic field sensing

05.12.2016 | Power and Electrical Engineering

Construction of practical quantum computers radically simplified

05.12.2016 | Information Technology

NASA's AIM observes early noctilucent ice clouds over Antarctica

05.12.2016 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>