The study is being presented at the American College of Cardiology 2012 Annual Scientific Session, March 24 to 26 in Chicago.
Using data from the global REACH Registry, researchers evaluated the magnitude of risk of diabetes mellitus on cardiovascular events in both men and women. Risk was estimated in men and women separately independent of patient age, ethnicity, and other cardiovascular risk factors.
Among the 64,000 eligible REACH patients, the four-year risk of major cardiovascular events (death, heart attack or stroke) increased incrementally in patients with diabetes treated with diet only, oral diabetes medications or insulin.
Male patients with type 2 diabetes treated with insulin but without prior CVD were a particular high-risk group, with an accelerated rate of new cardiovascular events compared to their female counterparts.
For instance, men with diabetes taking insulin had a 16 percent rate of major cardiovascular events over four years. Whereas, men with prior CVD without diabetes had a lower rate for these cardiovascular events, similar to women with diabetes taking insulin and women without diabetes but with prior CVD (about 13 percent).
The researchers concluded that men with diabetes taking insulin had a 70 percent increased risk for a first cardiovascular event compared to men with a known history of CVD having a recurrent event.
In addition, men with diabetes taking insulin were at a 40 percent higher risk than women.
Lower-risk patients (those with diabetes not taking insulin) and very high-risk patients (those with both diabetes and CVD) had no apparent gender-risk differences.
"These findings suggest that both men and women with diabetes with severe insulin resistance (those patients requiring insulin) are at high risk for cardiovascular events, as high risk as patients who already have established cardiovascular disease," said Jacob Udell, MD, Cardiovascular Division, BWH Department of Medicine, and lead study investigator. "Given that the number of patients diagnosed with type 2 diabetes requiring insulin continues to increase, these patients require diligent cardiovascular risk factor management to potentially avoid a first cardiovascular event."
This research was supported by the Canadian Institutes for Health Research, Canadian Foundation for Women's Health, Sanofi-Aventis, Bristol-Myers Squibb, Waksman Foundation (Tokyo), and the World Heart Federation.
Brigham and Women's Hospital (BWH) is a 793-bed nonprofit teaching affiliate of Harvard Medical School and a founding member of Partners HealthCare, an integrated health care delivery network. BWH is the home of the Carl J. and Ruth Shapiro Cardiovascular Center, the most advanced center of its kind. BWH is committed to excellence in patient care with expertise in virtually every specialty of medicine and surgery. The BWH medical preeminence dates back to 1832, and today that rich history in clinical care is coupled with its national leadership in quality improvement and patient safety initiatives and its dedication to educating and training the next generation of health care professionals. Through investigation and discovery conducted at its Biomedical Research Institute (BRI), www.brighamandwomens.org/research, BWH is an international leader in basic, clinical and translational research on human diseases, involving more than 900 physician-investigators and renowned biomedical scientists and faculty supported by more than $537 M in funding. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies and the Women's Health Initiative. For more information about BWH, please visit www.brighamandwomens.org.
Marjorie Montemayor-Quellenberg | EurekAlert!
MRI contrast agent locates and distinguishes aggressive from slow-growing breast cancer
25.09.2017 | Case Western Reserve University
Investigators may unlock mystery of how staph cells dodge the body's immune system
22.09.2017 | Cedars-Sinai Medical Center
At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.
Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
25.09.2017 | Physics and Astronomy
25.09.2017 | Trade Fair News
25.09.2017 | Physics and Astronomy