"Early identification and treatment of depressive states should be evaluated as a potential intervention to improve long-term outcomes in ALI survivors," said first author O. Joseph Bienvenu, MD, PhD, associate professor of psychiatry and behavioral sciences. "Depressive symptoms are a potentially modifiable risk factor for later-onset physical impairment in these patients."
The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
A total of 186 mechanically ventilated patients with ALI were included in the study, with follow-up at 3, 6, 12 and 24 months following injury. Outcome measures included the Hospital Anxiety and Depression Scale (HADS), with a score ¡Ý8 indicating depressive symptoms, and dependencies in instrumental activities of daily living (IADLs), with ¡Ý2 impairments indicating impaired physical function.
The cumulative two-year incidence of depressive symptoms among the 147 patients without baseline depression was 40 percent, and the cumulative incidence of impaired physical function among the 112 patients without baseline impaired physical function was 66 percent. Incidence rates were highest at three-month follow-up and declined thereafter. The modal (most common) durations were >21 months for each outcome.
In multivariable analyses, education ¡Ü12 years was significantly associated with incident depressive symptoms, and depressive symptoms at last follow-up were significantly associated with incident impaired physical function.
There were some limitations to the study. Depressive symptoms were measured using a self-report questionnaire, not psychiatric diagnoses. Baseline depression was identified from medical records, which may have led to some inaccuracy regarding patients' baseline mood states. Lastly, the possible effects of treatment of depression or impaired physical function were not considered, and instances of depressive symptoms or impaired physical function that occurred but resolved may have been missed.
"Depressive symptoms are not only persistent in ALI survivors but are a risk factor for subsequent impairment in physical function in ALI survivors," said last author Dale M. Needham, MD, PhD, associate professor of pulmonary and critical care medicine. "Given our findings, the early identification and treatment of depressive symptoms should be evaluated as part of the comprehensive rehabilitation of these patients, to determine if such an intervention would improve not only mood states but physical functioning."
About the American Journal of Respiratory Research and Critical Care Medicine:
With an impact factor of 10.191, the AJRRCM is a peer-reviewed journal published by the American Thoracic Society. It aims to publish the most innovative science and the highest quality reviews, practice guidelines and statements in the pulmonary, critical care and sleep-related fields.
Founded in 1905, the American Thoracic Society is the world's leading medical association dedicated to advancing pulmonary, critical care and sleep medicine. The Society's 15,000 members prevent and fight respiratory disease around the globe through research, education, patient care and advocacy.
Nathaniel Dunford | EurekAlert!
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Life Sciences
24.02.2017 | Life Sciences
24.02.2017 | Trade Fair News