Crucial to multicellular organisms, p53 is a tumor suppressor that regulates the cell cycle and helps prevent cancer by maintaining genetic stability and inhibiting gene mutation. But after irradiation, p53 deficiency results in abnormal levels of SUV39H1 and JMJD2b, enzymes that play a vital role in the structure of chromosomes, especially in DNA damage control and repair.“Different tumor types have variable responses to ionizing radiation,” explained study lead author Jiandong Chen, Ph.D., senior member of the Cancer Biology and Molecular Medicine Program at Moffitt. “Radiation therapy is more effective if tumors are defective in repairing damaged DNA. The p53 pathway is compromised to different degrees in all tumors, which may explain the fact that radiation often kills tumor cells more than normal cells.”
Kim Polacek | EurekAlert!
How cancer metastasis happens: Researchers reveal a key mechanism
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Researchers identify new way to unmask melanoma cells to the immune system
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On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
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