This is the first study describing change in multiple domains of cognitive functioning in order to determine which specific abilities are most affected in individuals with impaired renal function.
Researchers from Temple, University of Maine and University of Maryland examined longitudinal data, five years apart, from 590 people. They wanted to see how much kidney function had changed over that time period, and whether it was associated with how much cognitive functioning had changed. They were interested in the overall change, but also in specific abilities such as abstract reasoning and verbal memory.
"The brain and kidney are both organs that are affected by the cardiovascular systems," said the study's lead author, Adam Davey, associate professor of public health in Temple's College of Health Professions and Social Work. "They are both affected by things like blood pressure and hypertension, so it is natural to expect that changes in one organ are going to be linked with changes in another."
What the researchers found was the greater a person's decrease in renal functioning, the greater the decrease in overall cognitive functioning, particularly abstract reasoning and verbal memory.
"Those two tracked together, so this study provides us with evidence that the rate of cognitive decline is associated with deterioration in kidney function" said Davey.
Davey said that this information emphasizes two important points: the importance of diagnosing and managing chronic kidney disease and the extent of decrease in cognitive functioning.
"As we get older, our kidney function tends to decrease naturally, so if there's an extra issue involved in renal function like chronic kidney disease, we need to know about it as soon as possible," he said. "That is something that needs to be managed, just like you would manage hypertension."
Davey also noted that the decrease in cognitive functioning found in the study—when compared to people with dementia or cognitive impairment—is not so great that it would interfere with people being able to assist in their treatment of kidney disease.
"Patients are still going to be able to take their medicine on time and without assistance, as well as understand the information that their physician is sharing with them about their disease," he said.
In addition to Davey, researchers in this study included Merrill Elias, Michael Robbins and Gregory Dore of the University of Maine's Department of Psychology and School of Biomedical Sciences and Stephen L. Seliger of the University of Maryland's School of Medicine.
The researchers published their findings, "Decline in Renal Functioning is Associated with Longitudinal Decline in Global Cognitive Functioning, Abstract Reasoning, and Verbal Memory," in the journal Nephrology, Dialysis and Transplantation.
The study was funded by grants from the National Heart, Lung and Blood Institute and the National Institute on Aging at the National Institutes of Health to Temple University and the University of Maine.
Copies of this study are available to working journalists and may be obtained by contacting Preston M. Moretz in Temple's Office of University Communications at email@example.com
Preston M. Moretz | EurekAlert!
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Disrupted fat breakdown in the brain makes mice dumb
19.05.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.
Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...
22.05.2017 | Event News
17.05.2017 | Event News
16.05.2017 | Event News
22.05.2017 | Materials Sciences
22.05.2017 | Life Sciences
22.05.2017 | Physics and Astronomy