Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Data shows VisionGate's 3D imaging platform accurately detects lung cancer in sputum

28.10.2013
Data at IASLC demonstrate feasibility of using sputum and the Cell-CT platform to non-invasively detect the presence or absence of lung cancer; initially for adjunctive use with x-ray CT screening to address high rate of false positive results

VisionGate, Inc., a company developing a revolutionary non-invasive test for the early detection of lung cancer, today reported clinical data showing that its automated 3D cell imaging platform, the Cell-CT™, can detect lung cancer in sputum samples with high sensitivity and specificity. The data was presented at the International Association for the Study of Lung Cancer (IASLC) 15th World Conference on Lung Cancer.


VsionGate's Cell-CT platform creates strikingly clear and comprehensive 3D digital images of the cells contained in sputum. It uses advanced algorithms to identify the presence or absence of cell biosignatures associated with malignant or normal states, making it possible to determine with great accuracy whether or not an individual has lung cancer

Credit: VisionGate, Inc.

The pilot study analyzed sputum samples from patients with confirmed lung cancer and from healthy individuals. The results show that VisionGate's Cell-CT platform and LuCED® sputum test accurately detected the presence or absence of lung cancer cells in patient sputum from a spontaneous cough. In the 53 individuals studied to date, LuCED and the Cell-CT achieved a sensitivity of more than 95% and specificity of 99.8%. The high sensitivity indicates that the Cell-CT detects most cancers, and the high specificity means that the rate of false positive readings is exceedingly low. This is far greater accuracy than has been demonstrated with any other lung cancer screening test.

"Lung cancer remains the leading cause of cancer death in the U.S., primarily because it is not detected until after the cancer has spread," commented Alan Nelson, Ph.D., Founder and CEO of VisionGate. "Results to date from this ongoing clinical study suggest that LuCED and the Cell-CT correctly identify more than nine out of every ten cases of lung cancer with virtually no false positive results, supporting the goal of developing a new lung cancer screening paradigm that is both accurate and cost-effective."

The automated Cell-CT platform creates strikingly clear and comprehensive 3D digital images of the cells contained in sputum. It uses advanced algorithms to identify the presence or absence of cell biosignatures associated with malignant or normal status, making it possible to determine with great accuracy whether or not an individual has cancer.

Low-dose x-ray computed tomography (CT) screening can detect lung cancer at early stages and save lives. But x-ray CT screening has a very high rate of false positive results, which can require costly and invasive follow-up procedures. The large National Cancer Institute (NCI) National Lung Screening Trial showed that more than 96% of the "positive" results from x-ray CT screening were actually false positives. As a result, its use is recommended only in the highest-risk individuals. The potential ability of VisionGate's Cell-CT platform to non-invasively and cost-effectively confirm or refute positive results from x-ray CT scans would make widespread use of lung cancer screening far more feasible.

Glen J. Weiss, M.D., Director of Clinical Research, Cancer Treatment Centers of America® Western Regional Medical Center, noted, "The urgency of developing accurate, cost-effective tools for early detection of lung cancer is highlighted by the thousands of preventable lung cancer deaths each year. This data showing that the Cell-CT platform can detect lung cancer with high accuracy from sputum samples in patients at all stages of the disease, as well as identifying those who are cancer-free, is very encouraging. We look forward to continuing to work with VisionGate to enlarge the study population and generate the data needed to advance development of this promising lung cancer screening test."

Previous studies had confirmed that analyzing cells in sputum could be useful in the early detection of lung cancer. However, the typically poor sensitivity of raw sputum analysis and the labor-intensive nature of the process made it impracticable for widespread use. The Cell-CT's high resolution 3D technology and its automated image analysis software for the first time make a cell-based diagnostic approach using sputum samples logistically feasible and cost-effective.

Scarlett Spring, President of VisionGate, added, "We soon expect to supplement these exciting efficacy results with peer-reviewed economic analysis data that confirm the cost-effectiveness of our approach. We also are expanding our collaborative efforts with a variety of institutions as we focus on generating the additional data needed to gain FDA regulatory clearance of LuCED and the Cell-CT platform for adjunctive use with x-ray CT screening, and then possibly as a stand-alone test for lung cancer screening that would be readily available at moderate cost to the broader population."

The VisionGate data were contained in poster P1.20-006, "Non-invasive Detection of Lung Cancer from Cells in Sputum Using Cell-CT™," which was presented on October 28, 2013.

The IASLC's 15th World Conference on Lung Cancer is being held in Sydney, Australia from October 27-30, 2013. For more information, visit http://www.2013worldlungcancer.org/

About VisionGate

VisionGate, Inc., is developing a revolutionary non-invasive test for the early detection of lung cancer using its automated 3D cell imaging platform, the Cell-CT™, that generates high-resolution 3D biosignatures from cells in a sputum sample. The company's LuCED® test is initially being developed for adjunctive use with low dose x-ray computed tomography (CT) screening for the early detection of lung cancer. Adjunctive use of LuCED to better manage the high rate of false positive results in CT screening could increase the utility and cost-effectiveness of the approach, which has been shown to decrease lung cancer mortality in former and current smokers. For more information, please visit: http://www.visiongate3D.com.

Barbara Lindheim | EurekAlert!
Further information:
http://www.bllbiopartners.com
http://www.visiongate3D.com
http://www.2013worldlungcancer.org/

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>