Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New data for determining the epidemiology and improving the treatment of neuroendocrine tumours

29.11.2010
The National Cancer Registry of Spain for Gastroenteropancreatic Neuroendocrine Tumours (RGETNE) is the first initiative of its type in southern Europe and focuses its efforts on profiling the incidence of gastroenteropancreatic tumours, improving diagnosis and treatment efficacy, and determining the clinical profile of patients across Spain. An article published in the prestigious journal Annals of Oncology reveals the major findings of this national registry, based on a study contributed to by the University of Barcelona experts Carles Villabona-Artero, from the Department of Clinical Sciences, and Antoni Monleón-Getino, from the Department of Statistics, as well as Ramon Salazar, from the Catalan Institute of Oncology (ICO) and the Bellvitge Institute of Biomedical Research (IDIBELL).

Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are a group of low-incidence neoplasms with a wide spectrum of clinical behaviour and an annual incidence of 1-2 cases per 100,000 inhabitants in Europe and the United States. The complex epidemiology of these tumours poses a major challenge to researchers and to the specialist physicians and surgeons who treat them.

According to the article appearing in Annals of Oncology, which reviews a total of 907 tumours recorded in the RGETNE, the most common types in Spain are carcinoids (55%), pancreatic nonfunctional tumours (20%), metastatic NETs of unknown primary (9%), insulinomas (8%) and gastrinomas (4%). The registry reveals new information about the epidemiology and prognosis of GEP-NETs in Spain and current clinical practices, providing valuable information for improving our understanding of the regional disparities in the incidence, patterns of care and survival of this heterogeneous disease across different continents and countries. The cross-disciplinary, multi-centre study was directed by the researcher Rocío García-Carbonero (Hospital Virgen del Rocío, Seville) and is the widest study of GEP-NETs to have been conducted in southern Europe.

Participants in the nationwide study include the expert Carles Villabona-Artero, a professor with the UB’s Department of Clinical Sciences and practising endocrinologist at the Hospital de Bellvitge, who contributed a large number of clinical cases to the RGETNE registry, which stores data provided by researchers from across Spain in a unified database. Antoni Monleón-Getino, a professor with the UB’s Department of Statistics and technical coordinator of the RGETNE, was responsible for the complex statistical analysis of the extensive clinical data gathered, which involved continuous re-design and adaptation of the electronic registry to accommodate changes in clinical practice and the exact pathologies of patients.

The Spanish Scientific Society of Neuroendocrine Tumors (GETNE), directed by Ramon Salazar, a researcher for the ICO and IDIBELL, was set up in 2005 to improve the diagnosis and treatment of patients with neuroendocrine tumours in a national cross-disciplinary context. In addition to setting up the RGETNE, at the request of the Spanish Society of Endocrinology and Nutrition (SEEN) and the Spanish Cooperative Group for Group for Digestive Tract Tumor Therapy (TTD), the GETNE has been particularly active in promoting scientific projects and initiatives focusing on scientific and clinical aspects of endocrine tumours.

The results published in Annals of Oncology highlight the scientific value of the National Cancer Registry of Spain (RGETNE) – which will eventually be integrated into a unified European registry – in furthering our understanding of NET-GEPs and their evolution at the national level. It is hoped that this new knowledge will make a decisive contribution to improving the diagnosis, treatment and quality of life of affected patients.

Full bibliographic information
Garcia-Carbonero, R.; Capdevila, J.; Crespo-Herrero, G.; Díaz-Pérez, J. A.; Martínez del Prado, M. P.; Alonso Orduña, V.; Sevilla-García, I.; Villabona-Artero, C.; Beguiristain-Gómez, A.; Llanos-Muñoz, M.; Marazuela, M.; Alvarez-Escola, C.; Castellano, D.; Vilar, E.; Jiménez-Fonseca, P.; Teulé, A.; Sastre-Valera, J.; Benavent-Viñuelas, M.; Monleon, A.; Salazar, R. “Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): results from the National Cancer Registry of Spain (RGETNE)”. Annals of Oncology, 2010, doi: 10.1093/annonc/mdq022.

Rosa Martínez | alfa
Further information:
http://www.ub.edu

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>