Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are a group of low-incidence neoplasms with a wide spectrum of clinical behaviour and an annual incidence of 1-2 cases per 100,000 inhabitants in Europe and the United States. The complex epidemiology of these tumours poses a major challenge to researchers and to the specialist physicians and surgeons who treat them.
According to the article appearing in Annals of Oncology, which reviews a total of 907 tumours recorded in the RGETNE, the most common types in Spain are carcinoids (55%), pancreatic nonfunctional tumours (20%), metastatic NETs of unknown primary (9%), insulinomas (8%) and gastrinomas (4%). The registry reveals new information about the epidemiology and prognosis of GEP-NETs in Spain and current clinical practices, providing valuable information for improving our understanding of the regional disparities in the incidence, patterns of care and survival of this heterogeneous disease across different continents and countries. The cross-disciplinary, multi-centre study was directed by the researcher Rocío García-Carbonero (Hospital Virgen del Rocío, Seville) and is the widest study of GEP-NETs to have been conducted in southern Europe.
Participants in the nationwide study include the expert Carles Villabona-Artero, a professor with the UB’s Department of Clinical Sciences and practising endocrinologist at the Hospital de Bellvitge, who contributed a large number of clinical cases to the RGETNE registry, which stores data provided by researchers from across Spain in a unified database. Antoni Monleón-Getino, a professor with the UB’s Department of Statistics and technical coordinator of the RGETNE, was responsible for the complex statistical analysis of the extensive clinical data gathered, which involved continuous re-design and adaptation of the electronic registry to accommodate changes in clinical practice and the exact pathologies of patients.
The Spanish Scientific Society of Neuroendocrine Tumors (GETNE), directed by Ramon Salazar, a researcher for the ICO and IDIBELL, was set up in 2005 to improve the diagnosis and treatment of patients with neuroendocrine tumours in a national cross-disciplinary context. In addition to setting up the RGETNE, at the request of the Spanish Society of Endocrinology and Nutrition (SEEN) and the Spanish Cooperative Group for Group for Digestive Tract Tumor Therapy (TTD), the GETNE has been particularly active in promoting scientific projects and initiatives focusing on scientific and clinical aspects of endocrine tumours.
The results published in Annals of Oncology highlight the scientific value of the National Cancer Registry of Spain (RGETNE) – which will eventually be integrated into a unified European registry – in furthering our understanding of NET-GEPs and their evolution at the national level. It is hoped that this new knowledge will make a decisive contribution to improving the diagnosis, treatment and quality of life of affected patients.Full bibliographic information
Rosa Martínez | alfa
Improving memory with magnets
28.03.2017 | McGill University
Graphene-based neural probes probe brain activity in high resolution
28.03.2017 | Graphene Flagship
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
28.03.2017 | Life Sciences
28.03.2017 | Information Technology
28.03.2017 | Physics and Astronomy