Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


New data for determining the epidemiology and improving the treatment of neuroendocrine tumours

The National Cancer Registry of Spain for Gastroenteropancreatic Neuroendocrine Tumours (RGETNE) is the first initiative of its type in southern Europe and focuses its efforts on profiling the incidence of gastroenteropancreatic tumours, improving diagnosis and treatment efficacy, and determining the clinical profile of patients across Spain. An article published in the prestigious journal Annals of Oncology reveals the major findings of this national registry, based on a study contributed to by the University of Barcelona experts Carles Villabona-Artero, from the Department of Clinical Sciences, and Antoni Monleón-Getino, from the Department of Statistics, as well as Ramon Salazar, from the Catalan Institute of Oncology (ICO) and the Bellvitge Institute of Biomedical Research (IDIBELL).

Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are a group of low-incidence neoplasms with a wide spectrum of clinical behaviour and an annual incidence of 1-2 cases per 100,000 inhabitants in Europe and the United States. The complex epidemiology of these tumours poses a major challenge to researchers and to the specialist physicians and surgeons who treat them.

According to the article appearing in Annals of Oncology, which reviews a total of 907 tumours recorded in the RGETNE, the most common types in Spain are carcinoids (55%), pancreatic nonfunctional tumours (20%), metastatic NETs of unknown primary (9%), insulinomas (8%) and gastrinomas (4%). The registry reveals new information about the epidemiology and prognosis of GEP-NETs in Spain and current clinical practices, providing valuable information for improving our understanding of the regional disparities in the incidence, patterns of care and survival of this heterogeneous disease across different continents and countries. The cross-disciplinary, multi-centre study was directed by the researcher Rocío García-Carbonero (Hospital Virgen del Rocío, Seville) and is the widest study of GEP-NETs to have been conducted in southern Europe.

Participants in the nationwide study include the expert Carles Villabona-Artero, a professor with the UB’s Department of Clinical Sciences and practising endocrinologist at the Hospital de Bellvitge, who contributed a large number of clinical cases to the RGETNE registry, which stores data provided by researchers from across Spain in a unified database. Antoni Monleón-Getino, a professor with the UB’s Department of Statistics and technical coordinator of the RGETNE, was responsible for the complex statistical analysis of the extensive clinical data gathered, which involved continuous re-design and adaptation of the electronic registry to accommodate changes in clinical practice and the exact pathologies of patients.

The Spanish Scientific Society of Neuroendocrine Tumors (GETNE), directed by Ramon Salazar, a researcher for the ICO and IDIBELL, was set up in 2005 to improve the diagnosis and treatment of patients with neuroendocrine tumours in a national cross-disciplinary context. In addition to setting up the RGETNE, at the request of the Spanish Society of Endocrinology and Nutrition (SEEN) and the Spanish Cooperative Group for Group for Digestive Tract Tumor Therapy (TTD), the GETNE has been particularly active in promoting scientific projects and initiatives focusing on scientific and clinical aspects of endocrine tumours.

The results published in Annals of Oncology highlight the scientific value of the National Cancer Registry of Spain (RGETNE) – which will eventually be integrated into a unified European registry – in furthering our understanding of NET-GEPs and their evolution at the national level. It is hoped that this new knowledge will make a decisive contribution to improving the diagnosis, treatment and quality of life of affected patients.

Full bibliographic information
Garcia-Carbonero, R.; Capdevila, J.; Crespo-Herrero, G.; Díaz-Pérez, J. A.; Martínez del Prado, M. P.; Alonso Orduña, V.; Sevilla-García, I.; Villabona-Artero, C.; Beguiristain-Gómez, A.; Llanos-Muñoz, M.; Marazuela, M.; Alvarez-Escola, C.; Castellano, D.; Vilar, E.; Jiménez-Fonseca, P.; Teulé, A.; Sastre-Valera, J.; Benavent-Viñuelas, M.; Monleon, A.; Salazar, R. “Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): results from the National Cancer Registry of Spain (RGETNE)”. Annals of Oncology, 2010, doi: 10.1093/annonc/mdq022.

Rosa Martínez | alfa
Further information:

More articles from Health and Medicine:

nachricht Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection
24.10.2016 | Universität Basel

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Ice shelf vibrations cause unusual waves in Antarctic atmosphere

25.10.2016 | Earth Sciences

Fluorescent holography: Upending the world of biological imaging

25.10.2016 | Power and Electrical Engineering

Etching Microstructures with Lasers

25.10.2016 | Process Engineering

More VideoLinks >>>