Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Culprit responsible for severe systemic scleroderma complications in African-Americans found

10.05.2012
Researchers say 3 proteins linked to worse outcomes are found more often in blacks than Caucasians with a common form of scleroderma

A new analysis finds that compared to Caucasians, African-Americans with systemic scleroderma have more antibodies in the blood that are linked to severe complications and an increased likelihood of death. They say this finding, published today in Arthritis & Rheumatism, suggests physicians can use these disease markers to screen and treat scleroderma patients proactively.

For the study, Georgetown University Medical Center (GUMC) teamed up with researchers from the University of Pittsburgh School of Medicine to examine 35 years of data collected about the autoimmune disease.

According to the Scleroderma Foundation, there are an estimated 300,000 people in the United States who have scleroderma and about one third of them have the systemic form. While both localized and systemic scleroderma cause hardening of the skin, systemic scleroderma also causes damage to the blood vessels, muscles, and internal organs. Scleroderma occurs when a person's immune system mistakenly attacks and destroys healthy body tissue.

Previous studies suggest that systemic scleroderma is more common, occurs at a younger age and is more severe in African-Americans than Caucasians. Researchers set out to examine if there was a difference in antibodies found in the blood to see if that might explain why African-Americans with the disease often do worse.

Virginia D. Steen, M.D., professor of medicine at GUMC, and her colleagues at Pittsburgh analyzed data from the Pittsburgh Scleroderma Database. Steen helped develop the database,which includes demographic, clinical, autoantibody, organ involvement and survival information for 203 African-American and 2945 Caucasian scleroderma patients seen at the University of Pittsburgh Medical Center between 1972 and 2007.

"Our findings show that African-Americans were more likely to have certain antibodies linked to severe complications such as severe pulmonary fibrosis and gastrointestinal involvement," explains Steen. "These complications tend to be the culprit for people who die from severe cases of scleroderma."

The findings show that African-Americans had higher frequencies of certain scleroderma specific autoantibodies compared to Caucasians: anti-U3-RNP (40 percent vs. 2 percent), U1-RNP (16 percent vs. 7 percent) and anti-topoisomerase (27 percent vs. 21 percent). Anti-topoisomerase auto-antibodies in scleroderma are associated with a higher incidence of pulmonary fibrosis (scarring of the lungs) and greater disease severity, and in this study, African-American patients with this antibody had more frequent and more severe fibrosis than the Caucasians with this antibody.

Pulmonary fibrosis was also more severe in African-American patients with anti-U1 RNP auto-antibodies compared to Caucasian patients with this antibody but a difference in survival between the races was not apparent. Researchers determined that the auto-antibody anti-U3 RNP was linked to more severe gastrointestinal involvement in blacks compared to Caucasians.

"This information can help empower patients and their doctors to act more aggressively, if appropriate, when the person with scleroderma has these antibodies associated with worse outcomes," concludes Steen. "We believe early aggressive intervention will improve outcomes."

In addition to Steen, authors include Robyn T. Domsic, Mary Lucas, Noreen Fertig, Thomas A. Medsger, Jr., of the University of Pittsburgh School of Medicine. Funding for the database has been received from the American College of Rheumatology, Scleroderma Foundation and numerous other grants from foundations and organizations. Steen and her co-authors report having no personal financial interests related to the study.

About Georgetown University Medical Center

Georgetown University Medical Center is an internationally recognized academic medical center with a three-part mission of research, teaching and patient care (through MedStar Health). GUMC's mission is carried out with a strong emphasis on public service and a dedication to the Catholic, Jesuit principle of cura personalis -- or "care of the whole person." The Medical Center includes the School of Medicine and the School of Nursing & Health Studies, both nationally ranked; Georgetown Lombardi Comprehensive Cancer Center, designated as a comprehensive cancer center by the National Cancer Institute; and the Biomedical Graduate Research Organization (BGRO), which accounts for the majority of externally funded research at GUMC including a Clinical Translation and Science Award from the National Institutes of Health. In fiscal year 2010-11, GUMC accounted for 85 percent of the university's sponsored research funding.

Karen Mallet | EurekAlert!
Further information:
http://www.georgetown.edu

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>