Doctors are increasingly using a convenient blood glucose test for diagnosing diabetes and pre-diabetes, but a study by the University of Michigan's C.S. Mott Children's Hospital shows it's not the best way to diagnose diabetes in children.The hemoglobin A1c test has become the preferred way to diagnose diabetes among the millions of Americans who have diabetes but show no symptoms. The simple test measures longer-term blood sugar levels -- without requiring patients to fast overnight.
But U-M researchers say more study is needed before doctors can safely rely on using hemoglobin A1c for children.
"We found that hemoglobin A1c is not as reliable a test for identifying children with diabetes and pre-diabetes compared with adults," says study lead author Joyce M. Lee, M.D.,M.P.H., a pediatric endocrinologist at Mott Children's Hospital. "Using this test in children may lead to missed cases."
The study was published online ahead of print in Journal of Pediatrics and provides new insight on effectively diagnosing diabetes in children.
In 2010, the American Diabetes Association released guidelines recommending HbA1c be exclusively used for diagnosing diabetes in children and adults.
For the study, Mott researchers evaluated the testing results of 1,156 obese and overweight adolescents, ages 12-18. The ADA recommends screening only obese and overweight kids because their weight puts them at higher risk for developing diabetes.
According to the guidelines, individuals without symptoms would be classified as having diabetes if HbA1c values reach 6.5 percent and as having pre-diabetes if HbA1c values reached between 6 and 6.4 percent on two separate tests.
The U-M authors suggest that the cut-off point may need to be lower for kids.
Until more definitive studies are available, it's premature to use HbA1c for children, authors say. Others tests such as the fasting plasma glucose and 2-hour plasma glucose measurements have long been relied on by doctors to diagnose diabetes among adults and children, but, as HbA1c emerged, they were expected to be phased out of use.
Mott pediatricians say they still play an important role in diabetes care.
"Based on the study findings, a fasting blood glucose test should still be used for diagnosing diabetes in children," says Lee, a member of the Child Health Evaluation and Research (CHEAR) Unit in the U-M Division of General Pediatrics.
U-M authors: Joyce Lee, M.D., MPH; En-Ling Wu; Beth Tarini, M.D., M.S., William H. Herman, M.D., MPH, and Esther Yoon, M.D., MPH.
Funding: Authors were supported by National Institute of Diabetes and Digestive and Kidney Diseases; the Clinical Sciences Scholars Program at the U-M; National Institute of Child Health & Human Development , the National Institutes of Health, and the National Heart Lung and Blood Institute.
Reference: "Diagnosis of diabetes using Hemogloblin A1c: Should recommendations in adults be extrapolated to adolescents?," Journal of Pediatrics.Resources:
Shantell M. Kirkendoll | EurekAlert!
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy