Doctors are increasingly using a convenient blood glucose test for diagnosing diabetes and pre-diabetes, but a study by the University of Michigan's C.S. Mott Children's Hospital shows it's not the best way to diagnose diabetes in children.The hemoglobin A1c test has become the preferred way to diagnose diabetes among the millions of Americans who have diabetes but show no symptoms. The simple test measures longer-term blood sugar levels -- without requiring patients to fast overnight.
But U-M researchers say more study is needed before doctors can safely rely on using hemoglobin A1c for children.
"We found that hemoglobin A1c is not as reliable a test for identifying children with diabetes and pre-diabetes compared with adults," says study lead author Joyce M. Lee, M.D.,M.P.H., a pediatric endocrinologist at Mott Children's Hospital. "Using this test in children may lead to missed cases."
The study was published online ahead of print in Journal of Pediatrics and provides new insight on effectively diagnosing diabetes in children.
In 2010, the American Diabetes Association released guidelines recommending HbA1c be exclusively used for diagnosing diabetes in children and adults.
For the study, Mott researchers evaluated the testing results of 1,156 obese and overweight adolescents, ages 12-18. The ADA recommends screening only obese and overweight kids because their weight puts them at higher risk for developing diabetes.
According to the guidelines, individuals without symptoms would be classified as having diabetes if HbA1c values reach 6.5 percent and as having pre-diabetes if HbA1c values reached between 6 and 6.4 percent on two separate tests.
The U-M authors suggest that the cut-off point may need to be lower for kids.
Until more definitive studies are available, it's premature to use HbA1c for children, authors say. Others tests such as the fasting plasma glucose and 2-hour plasma glucose measurements have long been relied on by doctors to diagnose diabetes among adults and children, but, as HbA1c emerged, they were expected to be phased out of use.
Mott pediatricians say they still play an important role in diabetes care.
"Based on the study findings, a fasting blood glucose test should still be used for diagnosing diabetes in children," says Lee, a member of the Child Health Evaluation and Research (CHEAR) Unit in the U-M Division of General Pediatrics.
U-M authors: Joyce Lee, M.D., MPH; En-Ling Wu; Beth Tarini, M.D., M.S., William H. Herman, M.D., MPH, and Esther Yoon, M.D., MPH.
Funding: Authors were supported by National Institute of Diabetes and Digestive and Kidney Diseases; the Clinical Sciences Scholars Program at the U-M; National Institute of Child Health & Human Development , the National Institutes of Health, and the National Heart Lung and Blood Institute.
Reference: "Diagnosis of diabetes using Hemogloblin A1c: Should recommendations in adults be extrapolated to adolescents?," Journal of Pediatrics.Resources:
Shantell M. Kirkendoll | EurekAlert!
Improving memory with magnets
28.03.2017 | McGill University
Graphene-based neural probes probe brain activity in high resolution
28.03.2017 | Graphene Flagship
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
28.03.2017 | Life Sciences
28.03.2017 | Information Technology
28.03.2017 | Physics and Astronomy