The study of 47 human, benign adrenal gland tumors also showed a mutation of the gene KCNJ5 is twice as likely to occur in women – 71 versus 29 percent – as it points to potential new treatments for some patients who don't respond to current hypertension regimens, said Dr. William E. Rainey, Scientific Director of the Adrenal Center at Georgia Health Sciences University.
Addititionally, when scientists put the mutated gene into an adrenal cell, it immediately starts producing the sodium-retaining hormone aldosterone. "We found it turned on a whole series of genes that cause the cell to produce aldosterone," Rainey said.
Typically, KCNJ5 appears to help normalize levels of the sodium-retaining hormone aldosterone by regulating how much potassium is pumped in and out of aldosterone-producing cells on the outer layer of the adrenal glands. Abnormal protein produced by the mutated gene alters the cells' electrical status.
"When this gene has a mutation, the cells lose control and just start producing aldosterone all the time," said Rainey, corresponding author of the study in the Journal of Clinical Endocrinology and Metabolism.
"The combination of too much salt and too much of this hormone leads to high blood pressure and tissue damage," said Rainey. He notes that the vast majority of the 311 million Americans consume too much salt, even if they never pick up a salt shaker, because of high content in breads, processed and fast foods and the like. An estimated 33 percent of Americans are hypertensive and an estimated 1 in 10 have adrenal problems as the cause.
A 2011 study led by Yale University and published in the journal Science showed that the tumors had a KCNJ5 mutation. GHSU researchers, along with colleagues at University of Michigan Medical School, Ann Arbor; University of Torino and University of Padova, Italy; University of Texas Southwestern Medical Center, Dallas; and Keio University,Tokyo linked the gene to aldosterone production.
Now the GHSU Adrenal Center is moving forward with studies to determine why women with adrenal tumors have more of the mutated gene – Rainey suspects it's estrogen-related. They also want to know if any of the dozen potassium channel inhibitors already on the market for heart and other disorders can help these patients as well.
Rainey said the gene mutation is one that occurs after birth – when most mutations occur – and the cause is unknown. About half the people who produce too much aldosterone have tumors, which tend to affect only one of the 2-by-1-inch glands that sit like hats on top of the two kidneys and surgical removal typically fixes their problem. Unexplained enlargement of both glands likely also has a genetic basis and may be medically managed, Rainey said.
One of the many goals of the GHSU Adrenal Center, one of a handful of multidisciplinary centers in the nation, is to better define genes which can result in whole families being impacted. To date, only three genes are known to contribute to the familial form. Aldosterone excess, by whatever means, also is suspected when people under age 40 become hypertensive for no other obvious reason.
The adrenals are extremly efficient glands, producing three additional hormone groups that help maintain homeostasis including cortisol needed for glucose/carbohydrate metabolism, weak sex steroids that likely are the major source of androgens, or male hormones, in women; and the fight or flight hormones epinephrine and norepinephrine. In the event both glands are removed, the vital hormones must be supplemented, Rainey said.
Patients typically come to the GHSU Adrenal Center with unexplained hypertension that isn't responding to traditional therapy. "They are typically on three or four medications and their blood pressure is still not under control," said Dr. Michael A. Edwards, Clinical Director of the Adrenal Center and Chief of the MCG Section of Minimally Invasive and Digestive Diseases Surgery. Computerized tomography done for other reasons can detect over-sized glands or tumors that may be the culprit.
For more information, visit http://www.mcghealth.org/adrenal/GhsuContentPage.aspx?nd=367
Toni Baker | EurekAlert!
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.
Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...
16.03.2018 | Event News
13.03.2018 | Event News
08.03.2018 | Event News
16.03.2018 | Earth Sciences
16.03.2018 | Physics and Astronomy
16.03.2018 | Life Sciences