Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Common fragrance ingredients in shampoos and conditioners are frequent causes of eczema

27.03.2009
Considerably more people than previously believed are allergic to the most common fragrance ingredient used in shampoos, conditioners and soap. A thesis presented at the Sahlgrenska Academy, University of Gothenburg, Sweden found that over 5% of those who underwent patch testing were allergic to the air oxidized form of the fragrance ingredient linalool.

"I would suspect that about 2% of the complete population of Sweden are allergic to air oxidized linalool. That may not sound very much, but it is serious since linalool is so widely used as a fragrance ingredient.

Linalool is found in 60-80 percent of the perfumed hygiene products, washing up liquids and household cleaning agents that can be bought in the nearest supermarket, and it can be difficult for people who are allergic to avoid these products", says dermatologist Johanna Bråred Christensson, author of the thesis.

Around one person in five in Sweden has some form of contact allergy. Nickel is by far the most common substance that causes eczema, but the thesis shows that oxidized linalool occupies third place in the list, after nickel and cobalt.

In the study, oxidized linalool was added at patch testing for more than 3,000 patients who wanted to find out what was causing their eczema. Between 5% and 7% proved to be allergic to the oxidized form of the fragrance ingredient.

"Linalool is present in many products around us, and this is probably the reason that contact allergy to this material is so common. Some people can shower with shower cream that contains linalool but never develop contact allergy, but we know that the risk increases as the exposure to t! he substance increases", says Johanna Bråred Christensson.

Linalool is a fragrance ingredient found naturally in lavender, mint, and other plants. Linalool breaks down when it comes into contact with oxygen, it becomes oxidized and can cause allergy. Manufacturers do include other substances in the products to delay this oxidation process, but allergenic substances can st! ill be formed from linalool when it is stored.

"One way of trying to minimize exposure to oxidized linalool is to avoid buying large packs of soap and shower cream, and always to replace the top after using a bottle", says Johanna Bråred Christensson.!

EU legislation states that manufacturers must specify on the labels of hygiene products whether they contain linalool. Previous studies have shown that oxidized linalool may cause contact allergy in about 1% of patients with eczema.

BRIEF FACTS: COMMON CONTACT ALLERGENS
Around 10-15% of all Swedes are allergic to nickel, and this is the ! most common form of contact allergy. Another substance that may be present in imitation jewellery is cobalt, to which around 2 3% of the population is allergic. Linalool occupies third place in the list after nickel and cobalt. It has been estimated that 2% of all Swedes are allergic to linalool. Other substances that can cause contact allergy include various perfumes and preservatives.
The Sahlgrenska Academy
The Sahlgrenska Academy is the faculty of health sciences at the University of Gothenburg. Education and research are conducted within the fields of pharmacy, medicine, odontology and health care sciences.

About 4000 undergraduate students and 1000 postgraduate students are enrolled at Sahlgrenska Academy. The staff is about 1500 persons. 850 of them are researchers and/or teachers.

For more information contact:
Dermatologist Johanna Bråred Christensson, mobile: +46 (0)707 296118, e-mail: johanna.brared-christensson@vgregion.se
Supervisors:
Professor Ann-Therese Karlberg, telephone: +46 (0)31 772 4726, e-mail: karlberg@chem.gu.se
Associate professor Ann-Marie Wennberg, e-mail: ! ann-marie.wennberg@vgregion.se
Consultant Mihály Matura, e-mail: mihaly.matura@ki.se
Thesis presented for the degree of Doctor of Philosophy (Medicine) at the Sahlgrenska Academy, Institute of Clinical Sciences, Department of Dermatology and Venereology.

Thesis title: Clinical and Experimental Studies on Oxidized Fragrance Terpenes as Contact Allergens

This thesis is based on the following papers:
I. Air oxidation increases skin irritation from fragrance terpenes
Bråred Christensson J, Forsström P, Wennberg A-M, Karlberg A-T, Matura M.
Contact Dermatitis: 2009: 60: 32-40.
II. Oxidized linalool - a significant contact sensitizer
Bråred Christensson J, Matura M, Gruvberger B, Bruze M, Karlberg A-T.
Manuscript.
III. Hydroperoxides form specific antigens in contact allergy.
Bråred Christensson J, Matura M, Bäcktorp C, Börje A, Nilsson JLG, Karlberg A-T.
Contact Dermatitis: 2006; 55(4): 230-7.
IV. Limonene hydroperoxide analogues differ in allergenic activity.
Bråred Christensson J, Johansson S, Hagvall L, Jonsson C, Börje A, Karlberg A-T.
Contact Dermatitis: 2008; 59(6): 344-52.

Helena Aaberg | idw
Further information:
http://www.gu.se/
http://hdl.handle.net/2077/19052

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Shallow soils promote savannas in South America

20.10.2017 | Earth Sciences

How Obesity Promotes Breast Cancer

20.10.2017 | Life Sciences

How the smallest bacterial pathogens outwit host immune defences by stealth mechanisms

20.10.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>