Scientists with the UNC Lineberger Comprehensive Cancer Center reported their findings in the Sept. 26, 2011 online issue of the International Journal of Surgery.
Non-melanoma skin carcinoma (NMSC) is the most common malignancy worldwide with an incidence of over 1.3 million in the United States. These cancers occur in anatomic areas subject to frequent sun exposure such as the head and neck. Most of these cancers can be cured with local treatments such as surgery or radiation. Some cancers, however, are high risk, meaning they are biologically and clinically aggressive, and require more treatment, with characteristics such as large tumor size, regional nodal involvement or recurrent disease.
Because this patient population is small, there are limited data on optimal care for these cancers. Neil Hayes, MD, MPH, associate professor of medicine and senior author, explains, " Combination therapy is often used to treat other types of cancer, but not non-melanoma skin carcinoma. Our study provides the first evidence that this approach might be effective for this high-risk type of cancer. Skin cancer incidence is increasing worldwide, so having a more comprehensive and effective treatment regimen will help the patients with the most aggressive forms of this disease."
Scientists with the UNC Head and Neck Oncology Program conducted a retrospective study of 45 patients treated for NMSC with either concomitant radio- and chemotherapy or radiotherapy alone. They found that those treated with the combination therapy relapsed at rates that approximately half of those of patients who received radiation when accounting for other risk factors. While the relatively small size of the study does not definitively prove such a large benefit, it does offer strong support that this treatment approach should receive attention in future studies.
Hayes concludes, "This study provides preliminary data on the feasibility of combining chemotherapy concomitantly with radiotherapy and further studies are needed to fully assess toxicity and better define subsets of patients who might benefit from combined modality treatment."
Other UNC authors are Nirav Dhruva, MD; Farhad Ardeshirpour, MD; Joel Tepper, MD; Carol Shores, MD, PhD; Julian Rosenman, MD, PhD; William Shockley, MD; and Michele Hayward, RD.
Dianne Shaw | EurekAlert!
Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine
NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
21.11.2017 | Physics and Astronomy
21.11.2017 | Physics and Astronomy
21.11.2017 | Life Sciences