Artemisinin combination therapies (ACTs) could be almost as effective in reducing transmission of malaria as insecticide-treated bednets (ITNs) in areas of low transmission, a study based on data from Tanzania has found.
In high transmission areas, long-acting antimalarial regimens may be needed to achieve significant transmission reductions.
Experts from the London School of Hygiene & Tropical Medicine, with colleagues from Imperial College, London (UK) and Radboud Unversity in Nijmegen in the Netherlands used mathematical modelling to predict the potential impact on transmission outcomes of introducing ACT as the first-line treatment for uncomplicated malaria in six areas of Tanzania. The effects of ACT were estimated from clinical trial data. The findings of the study are published today in the journal PLoS Medicine.
The reductions in infection and clinical episodes of malaria were predicted to be highest in areas of low transmission, where it was estimated that a 53% decrease in clinical episodes might occur if all current treatments were switched to ACT. This compared to 21% in the areas with the highest transmission.
Lucy Okell, Research Degree Student at the London School of Hygiene & Tropical Medicine and lead author of the study, commented: 'Overall, we predict that at existing treatment rates, a 100% switch to ACT from non-artemisinin drugs could reduce the rate of clinical episodes of malaria by between 21 and 53% if a short-acting ACT such as artemether-lumefantrine was used.
The impact is smallest in the highest transmission settings, but it could be up to three times greater in these areas if a long-acting ACT regimen was used. As endemic countries gear up for malaria eradication, a target called for by the Bill and Melinda Gates Foundation in 2007, it will be important to know how choice of first-line treatment can help reach this goal’.
Gemma Howe | alfa
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
23.05.2017 | Event News
22.05.2017 | Event News
17.05.2017 | Event News
23.05.2017 | Physics and Astronomy
23.05.2017 | Life Sciences
23.05.2017 | Medical Engineering