Artemisinin combination therapies (ACTs) could be almost as effective in reducing transmission of malaria as insecticide-treated bednets (ITNs) in areas of low transmission, a study based on data from Tanzania has found.
In high transmission areas, long-acting antimalarial regimens may be needed to achieve significant transmission reductions.
Experts from the London School of Hygiene & Tropical Medicine, with colleagues from Imperial College, London (UK) and Radboud Unversity in Nijmegen in the Netherlands used mathematical modelling to predict the potential impact on transmission outcomes of introducing ACT as the first-line treatment for uncomplicated malaria in six areas of Tanzania. The effects of ACT were estimated from clinical trial data. The findings of the study are published today in the journal PLoS Medicine.
The reductions in infection and clinical episodes of malaria were predicted to be highest in areas of low transmission, where it was estimated that a 53% decrease in clinical episodes might occur if all current treatments were switched to ACT. This compared to 21% in the areas with the highest transmission.
Lucy Okell, Research Degree Student at the London School of Hygiene & Tropical Medicine and lead author of the study, commented: 'Overall, we predict that at existing treatment rates, a 100% switch to ACT from non-artemisinin drugs could reduce the rate of clinical episodes of malaria by between 21 and 53% if a short-acting ACT such as artemether-lumefantrine was used.
The impact is smallest in the highest transmission settings, but it could be up to three times greater in these areas if a long-acting ACT regimen was used. As endemic countries gear up for malaria eradication, a target called for by the Bill and Melinda Gates Foundation in 2007, it will be important to know how choice of first-line treatment can help reach this goal’.
Gemma Howe | alfa
Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan
Prospect for more effective treatment of nerve pain
20.02.2017 | Universität Zürich
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
21.02.2017 | Earth Sciences
21.02.2017 | Medical Engineering
21.02.2017 | Trade Fair News