Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cold-Blooded Research has Hearts Thumping

22.04.2013
The protective effect of inducing controlled hypothermia following sudden cardiac arrest will now be investigated in detail.

The goal of the scientific work is to judge whether this type of cryotherapy can be improved when using parallel simultaneous invasive resuscitation procedures. Establishing a powerful model to help predict improvements in patients' health is key for the project.


Green light for research on inducing controlled hypothermia following sudden cardiac arrest. Photo: Andreas Janata

Neuro-behavioural tests will also be developed to enable various treatment regimens to be compared. The project, supported by the Austrian Science Fund FWF, will establish the basis for best practices when saving lives using controlled hypothermia.

Things stay fresh longer when refrigerated. That goes for lettuce as well as humans – especially when the body is not provided with an adequate supply of oxygen. This occurs following sudden cardiac arrest, which has a survival rate of less than ten percent. Cooling to 33 degrees Celsius – known as mild hypothermia – is actually the only effective therapy for improving the survival rates of these patients. A team of researchers from the Medical University of Vienna will now investigate how to improve hypothermic treatment when using it in combination with invasive resuscitation procedures.

Resuscitation & Repairing

Hypothermia works by reduction of reperfusion injury – the damage that is inflicted by oxygenized blood flowing into oxygen-deprived tissue. As paradoxical as it may sound, the resuscitation that makes survival of the patient possible, likewise leads to damage of the heart muscle and brain. Dr. Andreas Janata from the Department of Emergency Medicine at the Medical University of Vienna and leader of the project on this topic: "Reperfusion injury occurs when blood flow is restored to the brain after a period of hypoxia, which is oxygen deprivation. Restoration of the blood flow actually triggers an inflammation reaction and oxidative stress that can damage the tissue. Hypothermia can reduce the effects of these mechanisms of damage." Current conventional protocols involve reducing the body temperature down to 33 degrees Celsius. According to the hypothesis, even lower temperatures would minimise damaging after-effects in the brain – but they would lead to intolerable side effects for the heart.

Dr. Janata and his team want to get a grip on precisely this treatment dilemma. For invasive resuscitation procedures using a heart-lung machine relieve the heart during resuscitation and thus allow the use of lower temperatures. However, the best temperature scheme is not yet known and the project will settle this.

Therapeutic Cocktail "on the Rocks"

Hypothermia influences a great many physiological processes, which is one of the challenges involved. These include programmed cell death (apoptosis), immune responses, and damage to nerve cells (excitotoxicity), as well as oxidative cellular stress. The processes affected are actually so complex that it would be difficult to identify any one single pharmaceutical therapy that could have just as comprehensive and positive an effect as hypothermia does. Dr. Janata comments: "Hypothermia is like a cocktail of various medications. That makes it very difficult to study its effect or determine the best practices for treatment." Due to this complexity, a significant part of the work begun recently by his team consists of setting up a suitable multi-tier model that permits analysis of various treatment regimens.

In fact, the team had already managed to develop models for ventricular fibrillations and invasive resuscitation some time ago. The project will now include developing neuro-behavioural tests for this model. These tests will be carried out following an induced circulatory arrest and permit the consequences of treatments with varying degrees of hypothermia during invasive resuscitative procedures to be compared. The results of this project, which is supported by the FWF, will then offer a basis for best-practices treatment in cases of sudden cardiac arrest – a medical problem that has exhibited frighteningly low survival rates, despite its frequent occurrence.

Scientific contact
Dr. Andreas Janata
Medical University of Vienna
Department of Emergency Medicine
Währinger Gürtel 18 - 20
1090 Vienna, Austria
M +43 / 650 / 314 7344
E andreas.janata@meduniwien.ac.at
Austrian Science Fund FWF
Mag. Stefan Bernhardt
Haus der Forschung
Sensengasse 1
1090 Vienna, Austria
T +43 / (0)1 / 505 67 40 - 8111
Copy Editing & Distribution
PR&D – Public Relations for Research & Education
Mariannengasse 8
1090 Vienna, Austria
T +43 / (0)1 / 505 70 44
E contact@prd.at
W http://www.prd.at

Judith Sandberger | PR&D
Further information:
http://www.fwf.ac.at

More articles from Health and Medicine:

nachricht Fiber optic biosensor-integrated microfluidic chip to detect glucose levels
29.04.2016 | The Optical Society

nachricht Got good fat?
27.04.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: 2+1 is Not Always 3 - In the microworld unity is not always strength

If a person pushes a broken-down car alone, there is a certain effect. If another person helps, the result is the sum of their efforts. If two micro-particles are pushing another microparticle, however, the resulting effect may not necessarily be the sum their efforts. A recent study published in Nature Communications, measured this odd effect that scientists call “many body.”

In the microscopic world, where the modern miniaturized machines at the new frontiers of technology operate, as long as we are in the presence of two...

Im Focus: Tiny microbots that can clean up water

Researchers from the Max Planck Institute Stuttgart have developed self-propelled tiny ‘microbots’ that can remove lead or organic pollution from contaminated water.

Working with colleagues in Barcelona and Singapore, Samuel Sánchez’s group used graphene oxide to make their microscale motors, which are able to adsorb lead...

Im Focus: ORNL researchers discover new state of water molecule

Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid or solid states.

In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of...

Im Focus: Bionic Lightweight Design researchers of the Alfred Wegener Institute at Hannover Messe 2016

Honeycomb structures as the basic building block for industrial applications presented using holo pyramid

Researchers of the Alfred Wegener Institute (AWI) will introduce their latest developments in the field of bionic lightweight design at Hannover Messe from 25...

Im Focus: New world record for fullerene-free polymer solar cells

Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences (CAS). This work is about avoiding costly and unstable fullerenes.

Polymer solar cells can be even cheaper and more reliable thanks to a breakthrough by scientists at Linköping University and the Chinese Academy of Sciences...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

The “AC21 International Forum 2016” is About to Begin

27.04.2016 | Event News

Soft switching combines efficiency and improved electro-magnetic compatibility

15.04.2016 | Event News

Grid-Supportive Buildings Give Boost to Renewable Energy Integration

12.04.2016 | Event News

 
Latest News

Did you know that Heraeus PID lamps have been used in the measurement of air quality at the London airport?

02.05.2016 | Power and Electrical Engineering

Heraeus Noblelight at the Drupa 2016

02.05.2016 | Trade Fair News

Climate-exodus expected in the Middle East and North Africa

02.05.2016 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>