Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cobblestones fool innate immunity

29.11.2011
Coating the surface of an implant such as a new hip or pacemaker with nanosized metallic particles reduces the risk of rejection, and researchers at the University of Gothenburg, Sweden, can now explain why: they fool the innate immune system. The results are presented in the International Journal of Nanomedicine.

“Activation of the body’s innate immune system is one of the most common reasons for an implant being rejected,” explains Professor Hans Elwing from the University of Gothenburg’s Department of Cell and Molecular Biology. “We can now show why the body more easily integrates implants with a nanostructured surface than a smooth one.”

The researchers used a unique method to produce nanostructures on gold surfaces, creating gold particles just 10-18 nm in diameter and binding them to a completely smooth gold surface at carefully regulated distances. The result is something akin to a cobbled street in miniature.

Nanosized irregularities mimic body’s natural structures

Giving implants this cobbled surface reduces the activation of important parts of the innate immune system. This is because several of the proteins involved are of a similar size to these nanosized cobbles, and so do not change in appearance when they land on the surface. This gives the body a greater ability to integrate foreign objects such as implants, pacemakers and drug capsules into its own tissues, as well as reducing the risk of local inflammation.

“It may be that the innate immune system is designed to react to smooth surfaces, because these are not found naturally in the body,” says Elwing. “Some bacteria, on the other hand, do have a completely smooth surface.”

Modern nanotechnology makes it easy and cheap to surface-treat implants and drug capsules, but it will probably be several years before this becomes a reality in human medicine. The focus now is on customising titanium implants of various kinds.

Surface can be graded

“We’ve developed a graded surface with different cobbelstone package that we think can be used for bone implants,” says Elwing. “Bone is very hard on the outside but then gets softer, so it would be good to have hard integration on the surface and softer integration underneath. We reckon we can make titanium screws that are denser at the head of the screw so that they fuse best at the top. This kind of customisation is the future.”

Research into the body’s innate immune system was rewarded this year with the Nobel Prize in Physiology or Medicine.

The laboratory work was carried out at the University of Gothenburg, and the project is a collaboration between the BIOMATCELL centre of excellence in Gothenburg, SP Technical Research Institute of Sweden in Borås and Bactiguard AB in Stockholm.

The article “Immune complement activation is attenuated by surface nanotopography” by Mats Hulander, Anders Lundgren, Mattias Berglin, Mattias Ohrlander, Jukka Lausmaa and dx.doi.org/10.2147/IJN.S24578Hans Elwing was published in the International Journal of Nanomedicine:

Contact:
Hans-Björne Elwing, Department of Cell and Molecular Biology
Tel: +46 (0)31 786 2562
Mobile: +46 (0)733 604 607
hans.elwing@cmb.gu.se

Helena Aaberg | idw
Further information:
http://www.gu.se

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>