Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Clues to diabetes susceptibility in a snip (SNP)

01.12.2008
A genetic variant highly associated with diabetes is found in both East Asian and European populations

A RIKEN-led research group has uncovered a previously unreported locus or area of chromosome in which single nucleotide polymorphisms (SNPs) are highly associated with type 2 diabetes in populations of East Asian and European descent.

The finding could lead to a diagnostic test. And studies of the principal gene’s role in the development and progress of the disease could reveal useful target compounds for drugs to prevent or treat the condition.

Type 2 or adult onset diabetes affects more than 200 million people worldwide and that number is increasing. What makes people susceptible is not fully clear, but a combination of many genes and environmental factors is likely. Recent advances in the technology to find specific SNPs in an entire individual genome have made it possible to determine which SNPs or groups of SNPs are associated with particular diseases. Several studies involving type 2 diabetics in the US and Europe have already picked out at least 16 loci associated with their condition, but no one had investigated entire individual genomes of people of East Asian ancestry.

So researchers from RIKEN’s Center for Genomic Medicine in Yokohama and institutes in Japan, Denmark and Singapore compared SNPs of type 2 diabetics with those of non-diabetics in groups from those three countries. They report their findings in a letter to Nature Genetics1.

Initially the researchers conducted a genome-wide association study in Japan of more than 207,000 SNPs. Analyzing their results statistically, they selected the 8,323 SNPs most associated with the condition, and tested these further. Eventually they pared their original number of SNPs down to six from three loci. Two of those loci were known to be highly associated with type 2 diabetes from the earlier studies, but one, based around the gene KCNQ1, was new. When tested in populations of East Asian descent in Singapore and European descent in Denmark, it was highly associated with type 2 diabetes in them as well.

KCNQ1 encodes a protein involved in forming pores enabling potassium ions to move out of cells. Mutations in the gene are reported to cause significant problems in the heart, but also in the inner ear, stomach and several other organs.

“We now want to examine the role of KCNQ1 in type 2 diabetes using animal models or cell cultures,” says project leader Shiro Maeda. “And we wish to continue our studies to discover more susceptibility genes.”

Reference

1. Unoki, H., Takahashi, A., Kawaguchi, T., Hara, K., Horikoshi, M., Andersen, G., Ng, D.P.K., Holmkvist, J., Borch-Johnsen, K., Jørgensen, T., et al. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nature Genetics 40, 1098–1102 (2008).

The corresponding author for this highlight is based at the RIKEN Laboratory for Endocrinology and Metabolism

Saeko Okada | ResearchSEA
Further information:
http://www.rikenresearch.riken.jp/research/596/
http://www.researchsea.com

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>