Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New cancer therapy using ultra-violet C (UVC) pulse flash irradiation

22.08.2012
Medical scientists at Tokai University School of Medicine in Japan announce the development of a new cancer therapy using ultra violet C (UVC) pulses of light. Details of these findings will be described by Johbu Itoh at the International Congress of Histochemistry and Cytochemistry (ICHC 2012), 26–29 August, 2012, Kyoto.

Johbu Itoh at the Tokai University School of Medicine in Japan has developed a new and highly effective cancer therapy method where cancer cells are irradiation with ultraviolet C (UVC) light.


MCF7: neoplastic cell, COS7:non-neoplastic cell. The Ultra Violet C (UVC) pulse flash irradiation only selectivity caused death of neoplastic cells, and not non-neoplastic cells. © Tokai University

The new method employs high intensity-UVC pulse flash rays (UVCPFR) of a broad UVC spectrum (230 to 280 nm) produced by a modified UV-flash sterilization system (BHX200). The experiments showed the pulsed nature of the spectrum to enhance the efficiency of destruction of neoplastic cells.

Importantly, the research demonstrates that under the appropriate UVC irradiation conditions only neoplastic cell were destroyed, and non-neoplastic cells did not reach conditions of cell death.

Background, results, and implications

The well-known "a germicidal light" of low pressure mercury lamps (UV lamp) is widely used for sterilizing medical instruments. However, it takes several hours for the weak light from UV lamps to have their germicidal effects.

In contrast, the sterilization effects of UV pulsed flash rays (wavelengths of 230–280nm and peak wavelength of 248 nm) show promise as more efficient and rapid means of destroying a wider range of bacteria because this type of irradiation produces light whose energy is tens of thousands of times greater for a given area of irradiation, compared with conventional UV lamps (65W equivalency).

UVC pulse flash rays (UVCPFR) with 1–10 continuous flashes per second can be produced by powerful discharge of xenon gas. Johbu Itoh and colleagues at the Tokai University School of Medicine has developed and established UVCPFR therapy system for cancer therapy.

The researchers irradiated cells with pulsed light UVCPFR and caused functional disorder to produce cell injury and/or a functional obstruction only to neoplastic cells. Higher ultraviolet radiation sensitivity in the UVC range was observed in neoplastic cells compared to non-neoplastic cells. That is, a short burst of ultraviolet radiation was sufficient to selectively induce injury and death to neoplastic cells.

Furthermore, experiments showed UVCPFR to cause cell death within a few seconds. One of the major features of this method is that below a certain range of irradiation conditions, damage to intact or non-neoplastic cells can be largely ignored, and only neoplastic cells die. This method offers a simple means of reducing the burden on patients undergoing cancer therapy. Itoh and colleagues plan to deveop this system compatible for cancer treatment using endoscopy, laser microscopy, and other such light irradiation equipment.
For further information contact

Johbu Itoh, Ph.D.
Dept. of Cell Biology and Histology,
Education and Research Support Center
Tokai University School of Medicine
143 Shimokasuya Isehara Kanagawa 259-1193
Japan
TEL: +81-463-93-1121 Ext.2581
FAX: +81-463-91-1370
E-mail:itohj@is.icc.u-tokai.ac.jp

References
1. Japanese patent: 4712905
2. Website of the 14th International Congress of Histochemistry and Cytochemistry (ICHC 2012), 26 –29 August, 2012, Kyoto, Japan: http://www.acplan.jp/ichc2012/ (direct link below)

Source: Tokai University School of Medicine, Isehara, Japan.

Adarsh Sandhu | Research asia research news
Further information:
http://www.u-tokai.ac.jp
http://www.researchsea.com

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>