Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer Risk: Aspirin and Smoking Affect Aging of Genes

01.07.2014

The risk of developing cancer increases with age. Factors like smoking and regular aspirin use also affect the risk of cancer – although in the opposite sense. Researchers from the University of Basel were now able to show that aspirin use and smoking both influence aging processes of the female genome that are connected to colorectal cancer. The Journal of the National Cancer Institute has published their results.

Already in the 1990s, scientists discovered that regular use of aspirin over long periods of time decreases the cancer risk. Since then, numerous studies have confirmed the protective effect of the drug against different types of cancer. Regular aspirin use is said to reduce the risk to develop colorectal cancer by an average of 40%. However, it is unknown how exactly the drug influences the cancer risk.


Our lifestyle choices affect the aging processes of our genome which can cause cell transformation and cancer

(Fig.: Martin Oeggerli / Micronaut, in cooperation with FHNW.)

A research group led by Prof. Primo Schär, molecular geneticists at the Department of Biomedicine from the University of Basel and gastrointestinal specialist PD Dr. Kaspar Truninger, has now discovered a possible mechanism of how aspirin decreases the risk of cancer: It slows down certain aging processes of the genome - namely modifications that also play an important role in the development of tumors.

In order to analyze the relationships between lifestyle and genome aging, the researchers examined intestinal tissue samples of 546 healthy women over 50 years of age. They compared age-specific changes of gene markers, so-called DNA methylations, with the women's lifestyle factors regarding aspirin use, smoking, body mass index and hormonal replacement therapy. The most significant effects were measured for aspirin use and smoking.

... more about:
»Aging »Aspirin »Basel »Cancer »DNA »genes »markers »premature »tumors

Aging Markers

“Each cell's genome resembles a library that is full of bookmarks”, explains Schär. Thanks to these bookmarks, the cells know which genes to read, so that they can fulfill their specialized tasks as skin, muscle or intestinal cells. “But these markers are not very stable and change during the course of age. If, at certain parts of the genome, the change is to drastic, tumors can develop”, says Schär.

In this study, the researchers were able to show for the first time that this age-related decay of gene markers can be slowed down by the regular use of aspirin. Smoking on the other hand, accelerates the aging process. “Especially affected are genes that also play a role in the development of cancer”, says Dr. Faiza Noreen, research associate at the Department of Biomedicine from the University of Basel and first author of the study.

Truninger emphasizes that it would be premature to start taking aspirin solely for cancer prevention without consulting a doctor first – especially when regarding the potential side effects such as gastrointestinal bleeding.

Original source:
Noreen F, Röösli M, Gaj P, Pietrzak J, Weis S, Urfer P, Regula J, Schär P and Truninger K.
Modulation of Age- and Cancer Associated DNA Methylation Change in the Healthy Colon by Aspirin and Lifestyle.
http://jnci.oxfordjournals.org/content/106/7/dju161.abstract?keytype=ref&ijk...
Journal of the National Cancer Institute published online, 2014 106 (4): dju161
doi: 10.1093/jnci/dju161

Further information:
Prof. Primo Schär, Department of Biomedicine, University of Basel, phone: +41 (0)61 267 07 67, email: primo.schaer@unibas.ch

Olivia Poisson | Universität Basel
Further information:
http://www.unibas.ch

Further reports about: Aging Aspirin Basel Cancer DNA genes markers premature tumors

More articles from Health and Medicine:

nachricht Live imaging reveals how wound healing influences cancer
01.07.2015 | EMBO

nachricht Using bacterial 'fight clubs' to find new drugs
30.06.2015 | Vanderbilt University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: X-rays and electrons join forces to map catalytic reactions in real-time

New technique combines electron microscopy and synchrotron X-rays to track chemical reactions under real operating conditions

A new technique pioneered at the U.S. Department of Energy's Brookhaven National Laboratory reveals atomic-scale changes during catalytic reactions in real...

Im Focus: Iron: A biological element?

Think of an object made of iron: An I-beam, a car frame, a nail. Now imagine that half of the iron in that object owes its existence to bacteria living two and a half billion years ago.

Think of an object made of iron: An I-beam, a car frame, a nail. Now imagine that half of the iron in that object owes its existence to bacteria living two and...

Im Focus: Thousands of Droplets for Diagnostics

Researchers develop new method enabling DNA molecules to be counted in just 30 minutes

A team of scientists including PhD student Friedrich Schuler from the Laboratory of MEMS Applications at the Department of Microsystems Engineering (IMTEK) of...

Im Focus: Bionic eye clinical trial results show long-term safety, efficacy vision-restoring implant

Patients using Argus II experienced significant improvement in visual function and quality of life

The three-year clinical trial results of the retinal implant popularly known as the "bionic eye," have proven the long-term efficacy, safety and reliability of...

Im Focus: Lasers for Fast Internet in Space – Space Technology from Aachen

On June 23, the second Sentinel mission was launched from the space mission launch center in Kourou. A critical component of Aachen is on board. Researchers at the Fraunhofer Institute for Laser Technology ILT and Tesat-Spacecom have jointly developed the know-how for space-qualified laser components. For the Sentinel mission the diode laser pump module of the Laser Communication Terminal LCT was planned and constructed in Aachen in cooperation with the manufacturer of the LCT, Tesat-Spacecom, and the Ferdinand Braun Institute.

After eight years of preparation, in the early morning of June 23 the time had come: in Kourou in French Guiana, the European Space Agency launched the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Conference on Regenerative Medicine in Leipzig: Last chance to submit abstracts until 2 July

25.06.2015 | Event News

World Conference on Regenerative Medicine: Abstract Submission has been extended to 24 June

16.06.2015 | Event News

MUSE hosting Europe’s largest science communication conference

11.06.2015 | Event News

 
Latest News

Offshore wind park Westermost Rough officially inaugurated

01.07.2015 | Press release

Siemens Velaro train wins "Red Dot" award

01.07.2015 | Awards Funding

Liquids on Fibers - Slipping or Flowing?

01.07.2015 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>