The risk of developing cancer increases with age. Factors like smoking and regular aspirin use also affect the risk of cancer – although in the opposite sense. Researchers from the University of Basel were now able to show that aspirin use and smoking both influence aging processes of the female genome that are connected to colorectal cancer. The Journal of the National Cancer Institute has published their results.
Already in the 1990s, scientists discovered that regular use of aspirin over long periods of time decreases the cancer risk. Since then, numerous studies have confirmed the protective effect of the drug against different types of cancer. Regular aspirin use is said to reduce the risk to develop colorectal cancer by an average of 40%. However, it is unknown how exactly the drug influences the cancer risk.
Our lifestyle choices affect the aging processes of our genome which can cause cell transformation and cancer
(Fig.: Martin Oeggerli / Micronaut, in cooperation with FHNW.)
A research group led by Prof. Primo Schär, molecular geneticists at the Department of Biomedicine from the University of Basel and gastrointestinal specialist PD Dr. Kaspar Truninger, has now discovered a possible mechanism of how aspirin decreases the risk of cancer: It slows down certain aging processes of the genome - namely modifications that also play an important role in the development of tumors.
In order to analyze the relationships between lifestyle and genome aging, the researchers examined intestinal tissue samples of 546 healthy women over 50 years of age. They compared age-specific changes of gene markers, so-called DNA methylations, with the women's lifestyle factors regarding aspirin use, smoking, body mass index and hormonal replacement therapy. The most significant effects were measured for aspirin use and smoking.
“Each cell's genome resembles a library that is full of bookmarks”, explains Schär. Thanks to these bookmarks, the cells know which genes to read, so that they can fulfill their specialized tasks as skin, muscle or intestinal cells. “But these markers are not very stable and change during the course of age. If, at certain parts of the genome, the change is to drastic, tumors can develop”, says Schär.
In this study, the researchers were able to show for the first time that this age-related decay of gene markers can be slowed down by the regular use of aspirin. Smoking on the other hand, accelerates the aging process. “Especially affected are genes that also play a role in the development of cancer”, says Dr. Faiza Noreen, research associate at the Department of Biomedicine from the University of Basel and first author of the study.
Truninger emphasizes that it would be premature to start taking aspirin solely for cancer prevention without consulting a doctor first – especially when regarding the potential side effects such as gastrointestinal bleeding.
Noreen F, Röösli M, Gaj P, Pietrzak J, Weis S, Urfer P, Regula J, Schär P and Truninger K.
Modulation of Age- and Cancer Associated DNA Methylation Change in the Healthy Colon by Aspirin and Lifestyle.
Journal of the National Cancer Institute published online, 2014 106 (4): dju161 doi: 10.1093/jnci/dju161
Prof. Primo Schär, Department of Biomedicine, University of Basel, phone: +41 (0)61 267 07 67, email: email@example.com
Olivia Poisson | Universität Basel
Antibiotic effective against drug-resistant bacteria in pediatric skin infections
17.02.2017 | University of California - San Diego
Tiny magnetic implant offers new drug delivery method
14.02.2017 | University of British Columbia
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
17.02.2017 | Medical Engineering
17.02.2017 | Medical Engineering
17.02.2017 | Health and Medicine