Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Building bone from cartilage

15.02.2012
Orthopaedic researchers take the road less traveled

A person has a tumor removed from her femur. A soldier is struck by an improvised explosive device and loses a portion of his tibia. A child undergoes chemotherapy for osteosarcoma but part of the bone dies as a result.

Every year, millions of Americans sustain fractures that don't heal or lose bone that isn't successfully grafted. But a study presented at the Orthopaedic Research Society (ORS) 2012 Annual Meeting in San Francisco offers new hope for those who sustain these traumas.

Orthopaedic researchers with the University of California, San Francisco (UCSF), Orthopaedic Trauma Institute, have found a very promising, novel way to regenerate bone. "Cartilage graft induces bone that actually integrates with the host bone and vascularizes it," said Ralph S. Marcucio, PhD, Associate Professor, UCSF School of Medicine.

Cartilage graft is very different than the current methods used for bone grafting—autograft bone (a person's own bone) or allograft materials (donor bone). For various reasons, these two grafting techniques can result in poor graft integration and osteonecrosis.

"With millions of bone grafting procedures performed every year in just the United States, developing improved technologies could directly enhance patient care and clinical outcomes," Dr. Marcucio said.

Chelsea S. Bahney, PhD, Postdoctoral Scholar, UCSF School of Medicine, concedes their approach is less orthodox. "It is not the pathway that most people think about, but it made a lot more sense to follow the normal developmental mechanism."

"This cartilage is naturally bioactive. It makes factors that help induce vascularization and bone formation," added Dr. Bahney. "When people use a bone graft, it is often dead bone which requires something exogenous to be added to it or some property of the matrix in the graft."

Through a process called endochondral ossification, cartilage grafts produce new tissue that is very similar to the person's own bone. Without additional properties to it, the researchers found the cartilage graft integrated well and was fully vascularized.

"We're just taking a very similar cartilage that can induce bone formation, putting it into a bone defect and letting it just do its thing," Dr. Marcucio said.

In the study, the researchers chose a non-stabilized tibial fracture callus as a source of a cartilage graft. "Healing of the transplanted cartilage grafts supported our hypothesis by producing a well-vascularized bone that integrated well with the host," Dr. Bahney said.

"A cartilage graft could offer a promising alternative approach for stimulating bone regeneration," Dr. Marcucio said. "Future work will focus on developing a translatable technology suitable for repairing bone through a cartilage intermediate at a clinical level."

About the Orthopaedic Research Society (ORS):

The Orthopaedic Research Society (ORS) is the pre-eminent organization for the advancement of musculoskeletal research. It seeks to transform the future through global multidisciplinary collaborations—focusing on the complex challenges of orthopaedic treatment. The ORS advances the global orthopaedic research agenda through excellence in research, education, collaboration, communication and advocacy. The ORS Annual Meeting and publication of the Journal of Orthopaedic Research provide vital forums for the musculoskeletal community to communicate the current state of orthopaedic research.

Annie Hayashi | EurekAlert!
Further information:
http://www.ors.org

More articles from Health and Medicine:

nachricht GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University

nachricht Scientists re-create brain neurons to study obesity and personalize treatment
20.04.2018 | Cedars-Sinai Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Magnetic nano-imaging on a table top

20.04.2018 | Physics and Astronomy

Start of work for the world's largest electric truck

20.04.2018 | Interdisciplinary Research

Atoms may hum a tune from grand cosmic symphony

20.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>