To create this improved model for breast cancer studies, the researchers grafted tumor tissue from consenting breast cancer patients directly into mouse mammary glands, rather than the traditional approach, where the cancer cells are grown, or cultured, in the laboratory. They discovered that the grafts remained virtually identical to the original human breast cancer in structure, genetic makeup and behavior, unlike the methods that rely on cell cultures.
"The most surprising result was that the tumor grafts spread from the original site, or metastasized, just as they did in the human patients," said the study's principal investigator Alana Welm, Ph.D, assistant professor in the Department of Oncological Sciences and an HCI investigator . "For example, grafts of tumor tissue from patients whose cancer had spread to the lung also spread to the lungs of the mice that received them."
Most breast cancer deaths result from the disease spreading to other areas of the body such as the lymphatic system, lungs, liver, bones or brain.
In addition, researchers found that the successful grafts were nearly all from patients who developed the most aggressive forms of breast cancer and ultimately died of their disease.. This result reveals the modeling method's potential as a tool that, soon after a breast cancer diagnosis, could identify whether the tumor would be likely to spread, helping doctors select the best treatment approach for an individual patient's form of the disease.
"There is also the potential to develop similar models for other cancers using this method," says Welm. "We are already working on this with colon cancer tissues."
The study is a cooperative effort of HCI's Breast Disease Oriented Team, comprised of surgeons, medical and radiation oncologists, pathologists, and laboratory scientists. Other contributors included HCI's Comparative Oncology Resource, the Tissue Resource and Application Core, and ARUP Research Institute. The work was supported by funding from the U.S. Department of Defense Breast Cancer Research Program, the American Association for Cancer Research, the Breast Cancer Research Foundation, and Huntsman Cancer Foundation.
The mission of Huntsman Cancer Institute (HCI) at The University of Utah is to understand cancer from its beginnings, to use that knowledge in the creation and improvement of cancer treatments, to relieve the suffering of cancer patients, and to provide education about cancer risk, prevention, and care. HCI is a National Cancer Institute-designated cancer center, which means that it meets the highest national standards for cancer care and research and receives support for its scientific endeavors. HCI is also a member of the National Comprehensive Cancer Network (NCCN), a not-for-profit alliance of the world's leading cancer centers that is dedicated to improving the quality and effectiveness of care provided to patients with cancer. For more information about HCI, please visit www.huntsmancancer.org.
Linda Aagard | EurekAlert!
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