Breast cancer occurs more frequently in certain ethnic and racial groups, but the reasons behind these differences are not fully understood. To investigate the issue, Lisa Hines, ScD, of the University of Colorado at Colorado Springs led a study that considered how established breast cancer risk factors—including reproductive history, family history of breast cancer, menstrual history, hormone use, alcohol consumption, physical activity, height, and body mass index—might be involved in explaining some of the observed differences in the occurrence of breast cancer among racial and ethnic groups.
They studied breast cancer among women from the Southwest United States who were enrolled in the population-based, case-control 4-Corners Breast Cancer Study, which was designed to investigate factors that contribute to the difference in breast cancer incidence rates observed between Hispanic and non-Hispanic white women.
Prior studies have shown that non-Hispanic white women have a higher incidence of breast cancer than Hispanic women. In this current study, the researchers found that 62 percent to 75 percent of breast cancer cases among non-Hispanic white women were attributed to known breast cancer risk factors, compared with only 7 to 36 percent of cases among Hispanic women. Hispanic women were more likely to have characteristics associated with lower breast cancer risk, such as earlier age at first childbirth, having more children, shorter height, less hormone use, and less alcohol consumption. Among premenopausal women, taller height and family history of breast cancer were associated with increased risk in non-Hispanic white women but were not among Hispanic women. Among postmenopausal women, certain breast cancer risk factors in non-Hispanic whites (such as recent hormone therapy use and younger age at menarche) had no or only weak associations with breast cancer in Hispanics.
These findings suggest that many of the risk factors studied to date explain fewer of the breast cancer cases that arise in Hispanic women compared with non-Hispanic white women. "These differences are likely to contribute to disparities in breast cancer incidence rates, and could potentially reflect differences in breast cancer development among these ethnic groups," said Dr. Hines. For example, ethnic differences in genetic and environmental or lifestyle factors may affect individuals' susceptibility to the development of breast cancer.
The authors noted that the study's findings also indicate that the use of models to estimate a woman's risk of breast cancer that were developed from studies among non-Hispanic white populations need to be evaluated among other ethnic and racial populations.
Article: "Comparative analysis of breast cancer risk factors among Hispanic and non-Hispanic white women." Lisa M. Hines, Betsy Risendal, Martha L. Slattery, Kathy Baumgartner, Anna R. Giuliano, Carol Sweeney, Dana E. Rollison, and Tim Byers. Cancer; Published Online: April 26, 2010 (DOI: 10.1002/cncr.25154).
Author Contact: To arrange an interview with Prof. Hines please contact Tom Hutton, at the University of Colorado University Relations team on +1 (719) 255-3439 (office), +1 (719) 351-6519 (cell) or firstname.lastname@example.org
Claire Greenwell | EurekAlert!
Penn studies find promise for innovations in liquid biopsies
30.03.2017 | University of Pennsylvania School of Medicine
'On-off switch' brings researchers a step closer to potential HIV vaccine
30.03.2017 | University of Nebraska-Lincoln
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
30.03.2017 | Health and Medicine
30.03.2017 | Health and Medicine
30.03.2017 | Medical Engineering