A research group of the Tübingen University Hospital studied a small, body-derived molecule called di-methyl fumarate (DMF), hat is the first molecule improving both diseases psoriasis and multiple sclerosis. They found that this body-derived molecule strongly influences natures most potent ‘immune stimulators’, the dendritic cells that have recently been awarded by the Nobel Prize to Ralph Steinman.
Normally, dendritic cells should recognize danger caused by bacteria or viruses, alarm the immune system and raise protective responses. Unfortunately, when fooled, dendritic cells induce by error immunity against the body’s own cells and start to destroy them.The Tübingen team has now shown, that small molecules like DMF re-educate the dendritic cells and turn them into a cell that protects from tissue destruction, the so-called ‚type 2 dendritic cells’. Using complex series of experiments, they uncover the mechanisms underly-ing this ‘re-education of the dendritic cells’. This establishes general rules for the develop-ment of new, most likely safe drugs that will significantly improve the life of patients with se-vere autoimmune diseases, namely psoriasis or multiple sclerosis.
The University of Tübingen holds a patent on this principle.Published in the Journal of Experimental Medicine 2011, October online
Dr. Ellen Katz | idw
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The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
Transistors based on carbon nanostructures: what sounds like a futuristic dream could be reality in just a few years' time. An international research team working with Empa has now succeeded in producing nanotransistors from graphene ribbons that are only a few atoms wide, as reported in the current issue of the trade journal "Nature Communications."
Graphene ribbons that are only a few atoms wide, so-called graphene nanoribbons, have special electrical properties that make them promising candidates for the...
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