Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Body's fatty folds may help fight kidney failure

21.03.2014

Stem cells from the body's omentum may preserve and improve kidney function

A fatty fold of tissue within the abdomen that is a rich source of stem cells can help heal diseased kidneys when fused to the organs, according to a study conducted in rats. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), suggest that stem cells from within a chronic kidney disease patient's own abdomen could be used to preserve and possibly improve kidney function.

Although adult stem cells have shown promise in treating experimental acute kidney diseases, it's unknown whether they might also alleviate chronic kidney diseases. Such a treatment strategy would typically involve injecting cells frequently over a period of many months and years because stem cells do not survive in the body for more than a few days after injection.

Ashok Singh, PhD (John Stroger, Jr Hospital of Cook County) and his colleagues attempted to overcome this hurdle in rats with kidney disease by connecting the omentum, a fatty fold of tissue that lies close to the kidney and is a rich source of stem cells, to the kidney. "This maneuver allowed us to permanently lodge stem cells in contact with the diseased kidney," explained Dr. Singh.

... more about:
»CKD »Nephrology »abdomen »diseases »failure

After 12 weeks, the omentum remained fused to the kidney, which showed signs of improved function. "The progression of chronic kidney disease was slowed due to the continuous migration of stem cells from the omentum to the diseased kidney, resulting in healing of the kidney," said Dr. Singh.

The results indicate that stem cells indeed possess the power to slow or even reverse chronic kidney disease, provided the cells are allowed to remain in the diseased kidney for a prolonged period of time.

"Attaching the omentum, a supposedly useless organ lying close to the kidney, to the diseased kidney could be put into practice after some more developmental work," said Dr. Singh. "By this technique, patients would be using their own stem cells lying in the omentum to cure their kidneys without depending on outside sources of stem cells."

In an accompanying editorial, Christof Westenfelder, MD (University of Utah) noted that the data reported by Dr. Singh and his colleagues are "novel and scientifically interesting." After pointing to some limitations to the applicability of this technology to clinical CKD, he stated that "further studies are needed to fully define the complex nature of the omentum's ability to heal injured organs and to establish its potential utility in patients with renal diseases."

###

Highlights

  • In rats with kidney disease, functioning of the kidney improved when the organ was fused with the omentum, a fatty fold of tissue that lies close to the kidney and is a rich source of stem cells.
  • Stem cells from a chronic kidney disease patient's own omentum may help heal diseased kidneys without the need for an outside source of cells. 
  • 60 million people globally have chronic kidney disease. 

Study co-authors include Ignacio Garcia-Gomez, PhD, Nishit Pancholi, MD, Jilpa Patel, MD, K P Gudehithlu, PhD, Peter Hart, MD, George Dunea, MD, and J A L Arruda, MD.

Disclosures: The authors reported no financial disclosures.

The article, entitled "Activated Omentum Slows Progression of CKD," will appear online at http://jasn.asnjournals.org/ on March 13, 2014.

The editorial, entitled "Does the Greater Omentum ("Policeman of the Abdomen") Possess Therapeutic Utility in CKD?" will appear online at http://jasn.asnjournals.org/ on March 13, 2014.

The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Founded in 1966, and with more than 14,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.

Tracy Hampton | EurekAlert!
Further information:
http://www.nasw.org

Further reports about: CKD Nephrology abdomen diseases failure

More articles from Health and Medicine:

nachricht Real-time imaging of lung lesions during surgery helps localize tumors and improve precision
30.07.2015 | American Association for Thoracic Surgery

nachricht Experimental MERS vaccine shows promise in animal studies
29.07.2015 | NIH/National Institute of Allergy and Infectious Diseases

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Glaciers melt faster than ever

Glacier decline in the first decade of the 21st century has reached a historical record, since the onset of direct observations. Glacier melt is a global phenomenon and will continue even without further climate change. This is shown in the latest study by the World Glacier Monitoring Service under the lead of the University of Zurich, Switzerland.

The World Glacier Monitoring Service, domiciled at the University of Zurich, has compiled worldwide data on glacier changes for more than 120 years. Together...

Im Focus: Quantum Matter Stuck in Unrest

Using ultracold atoms trapped in light crystals, scientists from the MPQ, LMU, and the Weizmann Institute observe a novel state of matter that never thermalizes.

What happens if one mixes cold and hot water? After some initial dynamics, one is left with lukewarm water—the system has thermalized to a new thermal...

Im Focus: On the crest of the wave: Electronics on a time scale shorter than a cycle of light

Physicists from Regensburg and Marburg, Germany have succeeded in taking a slow-motion movie of speeding electrons in a solid driven by a strong light wave. In the process, they have unraveled a novel quantum phenomenon, which will be reported in the forthcoming edition of Nature.

The advent of ever faster electronics featuring clock rates up to the multiple-gigahertz range has revolutionized our day-to-day life. Researchers and...

Im Focus: Superfast fluorescence sets new speed record

Plasmonic device has speed and efficiency to serve optical computers

Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.

Im Focus: Unlocking the rice immune system

Joint BioEnergy Institute study identifies bacterial protein that is key to protecting rice against bacterial blight

A bacterial signal that when recognized by rice plants enables the plants to resist a devastating blight disease has been identified by a multi-national team...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Euro Bio-inspired - International Conference and Exhibition on Bio-inspired Materials

23.07.2015 | Event News

Clash of Realities – International Conference on the Art, Technology and Theory of Digital Games

10.07.2015 | Event News

World Conference on Regenerative Medicine in Leipzig: Last chance to submit abstracts until 2 July

25.06.2015 | Event News

 
Latest News

“Seeing” molecular interactions could give boost to organic electronics

03.08.2015 | Materials Sciences

Stroke: news about platelets

03.08.2015 | Life Sciences

Molecular Spies to Fight Cancer - Procedure for improving tumor diagnosis successfully tested

03.08.2015 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>