Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Body's fatty folds may help fight kidney failure

21.03.2014

Stem cells from the body's omentum may preserve and improve kidney function

A fatty fold of tissue within the abdomen that is a rich source of stem cells can help heal diseased kidneys when fused to the organs, according to a study conducted in rats. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), suggest that stem cells from within a chronic kidney disease patient's own abdomen could be used to preserve and possibly improve kidney function.

Although adult stem cells have shown promise in treating experimental acute kidney diseases, it's unknown whether they might also alleviate chronic kidney diseases. Such a treatment strategy would typically involve injecting cells frequently over a period of many months and years because stem cells do not survive in the body for more than a few days after injection.

Ashok Singh, PhD (John Stroger, Jr Hospital of Cook County) and his colleagues attempted to overcome this hurdle in rats with kidney disease by connecting the omentum, a fatty fold of tissue that lies close to the kidney and is a rich source of stem cells, to the kidney. "This maneuver allowed us to permanently lodge stem cells in contact with the diseased kidney," explained Dr. Singh.

... more about:
»CKD »Nephrology »abdomen »diseases »failure

After 12 weeks, the omentum remained fused to the kidney, which showed signs of improved function. "The progression of chronic kidney disease was slowed due to the continuous migration of stem cells from the omentum to the diseased kidney, resulting in healing of the kidney," said Dr. Singh.

The results indicate that stem cells indeed possess the power to slow or even reverse chronic kidney disease, provided the cells are allowed to remain in the diseased kidney for a prolonged period of time.

"Attaching the omentum, a supposedly useless organ lying close to the kidney, to the diseased kidney could be put into practice after some more developmental work," said Dr. Singh. "By this technique, patients would be using their own stem cells lying in the omentum to cure their kidneys without depending on outside sources of stem cells."

In an accompanying editorial, Christof Westenfelder, MD (University of Utah) noted that the data reported by Dr. Singh and his colleagues are "novel and scientifically interesting." After pointing to some limitations to the applicability of this technology to clinical CKD, he stated that "further studies are needed to fully define the complex nature of the omentum's ability to heal injured organs and to establish its potential utility in patients with renal diseases."

###

Highlights

  • In rats with kidney disease, functioning of the kidney improved when the organ was fused with the omentum, a fatty fold of tissue that lies close to the kidney and is a rich source of stem cells.
  • Stem cells from a chronic kidney disease patient's own omentum may help heal diseased kidneys without the need for an outside source of cells. 
  • 60 million people globally have chronic kidney disease. 

Study co-authors include Ignacio Garcia-Gomez, PhD, Nishit Pancholi, MD, Jilpa Patel, MD, K P Gudehithlu, PhD, Peter Hart, MD, George Dunea, MD, and J A L Arruda, MD.

Disclosures: The authors reported no financial disclosures.

The article, entitled "Activated Omentum Slows Progression of CKD," will appear online at http://jasn.asnjournals.org/ on March 13, 2014.

The editorial, entitled "Does the Greater Omentum ("Policeman of the Abdomen") Possess Therapeutic Utility in CKD?" will appear online at http://jasn.asnjournals.org/ on March 13, 2014.

The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Founded in 1966, and with more than 14,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.

Tracy Hampton | EurekAlert!
Further information:
http://www.nasw.org

Further reports about: CKD Nephrology abdomen diseases failure

More articles from Health and Medicine:

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Closing the carbon loop

08.12.2016 | Life Sciences

Applicability of dynamic facilitation theory to binary hard disk systems

08.12.2016 | Physics and Astronomy

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D

08.12.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>