“What surprised us most, though, is that PER2 targets one specific amino acid on the surface of the PPAR-gamma molecule,” Sassone-Corsi said. “This kind of specificity is very rare in cell biology, which makes it exciting, because it presents us with a singular target for drug development.”
Daniele Piomelli, Louise Turner Arnold Chair in Neurosciences at UCI, and Todd Leff, associate professor of pathology at Wayne State University in Detroit, collaborated on the study, which appears this month in Cell Metabolism.
Twenty-four-hour circadian rhythms regulate fundamental biological and physiological processes in almost all organisms. They anticipate environmental changes and adapt certain bodily functions to the appropriate time of day. Disruption of these cycles can profoundly influence human health and has been linked to obesity, diabetes, insomnia, depression, heart disease and cancer.
Last year, Sassone-Corsi helped discover that proteins involved with circadian rhythms and metabolism are intrinsically linked and dependent upon each other to ensure that cells operate properly and remain healthy.
Rajesh H. Amin and James G. Granneman of Wayne State University and UCI’s Benedetto Grimaldi, Marina Maria Bellet, Sayako Katada, Giuseppe Astarita and Jun Hirayama contributed to the current study, supported by the National Institutes of Health.
About the University of California, Irvine: Founded in 1965, UCI is a top-ranked university dedicated to research, scholarship and community service. Led by Chancellor Michael Drake since 2005, UCI is among the most dynamic campuses in the University of California system, with nearly 28,000 undergraduate and graduate students, 1,100 faculty and 9,000 staff. Orange County’s largest employer, UCI contributes an annual economic impact of $3.9 billion. For more UCI news, visit www.today.uci.edu.
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Tom Vasich | EurekAlert!
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The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
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The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
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Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
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