“What surprised us most, though, is that PER2 targets one specific amino acid on the surface of the PPAR-gamma molecule,” Sassone-Corsi said. “This kind of specificity is very rare in cell biology, which makes it exciting, because it presents us with a singular target for drug development.”
Daniele Piomelli, Louise Turner Arnold Chair in Neurosciences at UCI, and Todd Leff, associate professor of pathology at Wayne State University in Detroit, collaborated on the study, which appears this month in Cell Metabolism.
Twenty-four-hour circadian rhythms regulate fundamental biological and physiological processes in almost all organisms. They anticipate environmental changes and adapt certain bodily functions to the appropriate time of day. Disruption of these cycles can profoundly influence human health and has been linked to obesity, diabetes, insomnia, depression, heart disease and cancer.
Last year, Sassone-Corsi helped discover that proteins involved with circadian rhythms and metabolism are intrinsically linked and dependent upon each other to ensure that cells operate properly and remain healthy.
Rajesh H. Amin and James G. Granneman of Wayne State University and UCI’s Benedetto Grimaldi, Marina Maria Bellet, Sayako Katada, Giuseppe Astarita and Jun Hirayama contributed to the current study, supported by the National Institutes of Health.
About the University of California, Irvine: Founded in 1965, UCI is a top-ranked university dedicated to research, scholarship and community service. Led by Chancellor Michael Drake since 2005, UCI is among the most dynamic campuses in the University of California system, with nearly 28,000 undergraduate and graduate students, 1,100 faculty and 9,000 staff. Orange County’s largest employer, UCI contributes an annual economic impact of $3.9 billion. For more UCI news, visit www.today.uci.edu.
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Tom Vasich | EurekAlert!
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