In a presentation during the 20th European Congress of Psychiatry in Prague, Mayo Clinic psychiatrists will present a systematic literature review of prazosin in the treatment of nightmares. Researchers investigated 12 prazosin studies, four of which were randomized controlled trials.
"The studies showed the drug was well-tolerated and can take effect rapidly, within days to weeks, and some patients reported a return of nightmares when the course of prazosin was stopped," says Simon Kung, M.D., a Mayo Clinic psychiatrist and principal investigator of the study.
"There's not much available for treating nightmares in terms of medications, so prazosin is a promising option," Dr. Kung says.
He added that the literature review opens the possibility of widening the use of prazosin. "Because of the low side effects of prazosin as reported in these studies, it seems logical to extend the use of prazosin to non-PTSD nightmares."
For people who suffer from PTSD, one of the most distressing effects is the experience of nightmares; in particular, the kinds of dreams that ruin sleep with extremely frightening images of physical or emotional threats. Nightmares can be so severe that they can contribute to alcoholism, substance abuse and suicidal thinking.
One possible cause of nightmare symptoms, such as disrupted sleep, is the development of overstimulated chemical messenger norepinephrine receptors in the central nervous system.
"The thinking is that pharmacologic agents, like prazosin, that block these receptors may be ideal in treating nightmares," Dr. Kung says.
Prazosin is a hypertension medication that's been used, following research that began a decade ago, by some Veterans Administration hospitals to treat PTSD-related nightmares.Other investigators in the study include Maria Lapid, M.D., of the Mayo Clinic Department of Psychiatry and Psychology, and Zelde Espinel M.D., M.P.H., of the Universidad El Bosque, Bogota, Colombia.
Nick Hanson | EurekAlert!
Finnish research group discovers a new immune system regulator
23.02.2018 | University of Turku
Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy