Even small improvements can make a great difference in the long term. These are the conclusions of a thesis recently presented at the Sahlgrenska Academy, University of Gothenburg, Sweden.
The studies have been carried out by statistical analysis of patients' records for patients at several diabetes clinics in western Sweden. A large American study is also included in the thesis. New statistical methods and extensive data collection have made it possible to analyse and study in detail the effects of treatments in a long-term perspective.
"Our results show that the risk of complications 10-15 years after the start of treatment probably decreases significantly following even small improvements in blood glucose control. If the treatment of all Swedish diabetes patients could be even slightly improved, we believe that tens of thousands of cases of injuries to the eyes, kidneys, heart, nerves and brain could be prevented", says physician Marcus Lind, author of the thesis.
"The analysis shows that the long-acting insulin glargin gives patients in normal diabetes care better blood glucose control than they would have achieved if they had continued with the NPH insulin. Similarly, the rapidly acting insulin lispro gives better blood glucose control than the traditional regular insulin", says Marcus Lind.
Patients' records for just over 4,000 patients from several hospitals in western Sweden were examined in the studies of insulin glargine, and just over 1,000 records for insulin lispro.
Link to thesis: http://hdl.handle.net/2077/19641For more information contact:
Title of the thesis: Glycaemic control: evaluations of HbA1c as a risk factor and the effects of modern insulins in clinical practiceThe thesis will be defended on Thursday 23 April, 1.00 pm, in the Arvid Carlsson lecture theatre, Academicum, Medicinaregatan 3, Göteborg, Sweden.
The thesis is available for download on the internet at: http://hdl.handle.net/2077/19641BY: Elin Lindström Claessen
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