"Arterial spin labeling is a powerful technique that can help reduce the cost and complexity of examinations," said the study's lead author, Lukas Scheef, M.D., from the Department of Radiology at University of Bonn, Germany. "It can also be more readily repeated than methods that involve the use of contrast agents and radiotracers."
Schizophrenia is a chronic and severe brain disorder that affects approximately 2.4 million American adults, according to the National Institute of Mental Health. Symptoms can include hallucinations, delusions, disordered thinking, movement disorders, social withdrawal and cognitive deficits.
In the study, conducted at the University Hospital of Bonn in Germany, researchers used CASL MRI to compare cerebral blood flow in 11 non-medicated patients with schizophrenia and 25 healthy controls. The patient group included three women with a mean age of 36 years and eight men with a mean age of 32 years. The control group included 13 women (mean age, 29 years) and 12 men (mean age, 30 years).
The results revealed that compared to the healthy controls, the schizophrenic patients had extensive areas of hypoperfusion, or lower blood flow than normal in the frontal lobes and frontal cortex, anterior and medial cingulate gyri, and parietal lobes. These regions are associated with a number of higher cognitive functions including planning, decision making, judgment and impulse control.
Hyperperfusion, or increased blood flow, was observed in the cerebellum, brainstem and thalamus of the schizophrenic patients.
"Our CASL study revealed patterns of hypo- and hyperperfusion similar to the perfusion patterns observed in positron emission tomography (PET) and single photon emission computed tomography (SPECT) studies of schizophrenic patients," Dr. Scheef said.
Unlike PET and SPECT studies, CASL MR images can be quickly acquired without the use of ionizing radiation or contrast agents. In CASL MRI, arterial blood water is magnetically labeled in order to non-invasively measure cerebral blood flow.
"CASL MRI may allow researchers to gain a better understanding of schizophrenia," Dr. Scheef said. "In the long run, it may help to individualize and optimize treatment."
"Resting-State Perfusion in Non-Medicated Schizophrenic Patients: A Continuous Arterial Spin-Labeling 3.0-T MR Study." Collaborating with Dr. Scheef were Christoph Manka, M.D., Marcel Daamen, Kai-Uwe Kühn, M.D., Wolfgang Maier, M.D., Hans H. Schild, M.D., and Frank Jessen, M.D.
Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc. (http://radiology.RSNA.org/)
RSNA is an association of more than 44,000 radiologists, radiation oncologists, medical physicists and related scientists committed to excellence in patient care through education and research. (RSNA.org)
For patient-friendly information on MRI, visit RadiologyInfo.org.
Linda Brooks | EurekAlert!
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Disrupted fat breakdown in the brain makes mice dumb
19.05.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...
For the first time, scientists have succeeded in studying the strength of hydrogen bonds in a single molecule using an atomic force microscope. Researchers from the University of Basel’s Swiss Nanoscience Institute network have reported the results in the journal Science Advances.
Hydrogen is the most common element in the universe and is an integral part of almost all organic compounds. Molecules and sections of macromolecules are...
22.05.2017 | Event News
17.05.2017 | Event News
16.05.2017 | Event News
22.05.2017 | Materials Sciences
22.05.2017 | Life Sciences
22.05.2017 | Physics and Astronomy