When there is inflammation in the body, one of the primary defense mechanisms is the movement of white blood cells, known as neutrophils, from the bloodstream into the infected tissue. Neutrophils are specialized cells that kill microbes associated with infection. Although neutrophils are important, their excessive recruitment into tissues can result in damage and contribute to disease.
Current anti-inflammatory drugs block all inflammation in the body. However, these newly discovered molecules target only neutrophils and may offer a more tailored course of treatment for some diseases, for example to help people suffering from inflammatory diseases such as Inflammatory Bowel Disease (IBD).
"This class of novel anti-inflammatory agents set the stage to develop drugs for conditions that have recurrent or chronic inflammation, " says Stephen Robbins, Ph.D, a researcher at the University of Calgary Faculty of Medicine, senior study author and the Director of the Southern Alberta Cancer Research Institute. "The next step in our research will be to test their effectiveness in preclinical studies of inflammatory diseases, including IBD"
"We are excited by the possibility that this research may be clinically useful to alleviate some of the damage that occurs in conditions where chronic inflammation leads to tissue injury," says Elizabeth Long PhD, who is also a University of Calgary researcher and study author.
The study was published this week in the journal Proceedings of the National Academy of Science (PNAS). This study was funded by the Canadian Institute of Health Research and the Alberta Cancer Foundation.
Marta | EurekAlert!
'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS
New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
19.02.2018 | Materials Sciences
19.02.2018 | Materials Sciences
19.02.2018 | Life Sciences