Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Biphasic electrical stimulation: A strategy may bring hope to spinal cord injury patients

26.08.2013
Researchers at the Beihang University School of Biological Science and Medical Engineering, led by Dr. Yubo Fan, have discovered that Biphasic Electrical stimulation (BES), a non-chemical procedure, may be used as a strategy for preventing cell apoptosis in stem cell-based transplantation therapy.

The article describing their studies will be published in the August 2013 issue of Experimental Biology and Medicine. The scientists believe that their technique will be used for spinal cord injury patients in the future.

Spinal cord injury (SCI) is a serious disease of the central nervous system. According to Spinal Cord Injury Facts & Statistics, 250,000 Americans are spinal cord injured patients. Approximately 52% of spinal cord injured individuals are considered as paraplegic, and 47% patients are quadriplegic. In addition, 11,000 new injuries occur each year, and 82% are male.

Transplantation of Stem Cells is a potential clinical therapy for repair and regeneration of injured spinal cord, and brings new hope for patients. However, the survival rate of transplanted cells is relatively low because the cells are particularly vulnerable to apoptosis in the spinal cord. Factors proposed for causing such low survival include immune reactions, limited trophic factors and hypoxia. It appears that a lack of adequate growth factors plays an important role in the survival of transplanted cells. "We've shown for the very first time that BES may provide insight into preventing growth factor deprivation-triggered apoptosis in olfactory bulb neural precursor cells (OB NPCs)," said Yubo Fan, professor of Biological Science and Medical Engineering at Beihang and senior author. "These findings suggest that BES may thus be used as a strategy to improve cell survival and prevent cell apoptosis in stem cell-based transplantation therapies," Fan explained. The results may guide future efforts to restore functions lost after spinal cord injury.

The team of researchers investigated the protective effects of BES on growth factor-deprived apoptosis in OB NPCs. The NPCs were exposed to 12 h of BES. The results were that BES enhanced cell survival and prevented the apoptosis of NPCs caused by growth factor deprivation. The anti-apoptotic effect of BES was dependent on the activation of the PI3K/Akt signaling cascade and an increase in brain-derived neurotrophic factor (BDNF) production. "What was especially surprising and exciting was that a non-chemical procedure can prevent apoptosis in stem cells therapy for spinal cord injury patients," Fan said. "How BES precisely regulates the survival of exogenous stem cells is still unknown, but will be an extremely novel area of research on spinal cord injury in the future," Dr. Fan added.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "The fact that Biphasic Electrical Stimulation can improve the survival of neural precursor cells is truly exciting and will provide the basis for future studies that could lead to novel therapies for patients with spinal cord injury. I look forward to future advances in this field".

Experimental Biology and Medicine is a journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. The journal was first established in 1903. Experimental Biology and Medicine is the journal of the Society of Experimental Biology and Medicine. To learn about the benefits of society membership visit http://www.sebm.org. If you are interested in publishing in the journal please visit http://ebm.sagepub.com/.

Dr. Yubo Fan | EurekAlert!
Further information:
http://www.sebm.org

More articles from Health and Medicine:

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht On track to heal leukaemia
18.01.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

New Study Will Help Find the Best Locations for Thermal Power Stations in Iceland

19.01.2017 | Earth Sciences

Not of Divided Mind

19.01.2017 | Life Sciences

Molecule flash mob

19.01.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>