The findings, which are published today in The EMBO Journal, could have implications for the treatment of inflammatory bowel disease as well as allergic, metabolic and infectious disorders.
“It is well-known that mammals live in a homeostatic symbiosis with their gut microbiota and that they influence a wide range of physiological processes. However, the molecular mechanisms of the symbiotic cross-talk in the gut are largely unrecognized,” stated Andrew S. Neish, Professor at the Emory University School of Medicine, who led the research. “In our study, we have discovered that Lactobacilli can stimulate reactive oxygen species that have regulatory effects on intestinal stem cells, including the activation of proliferation of these cells.”
Using two different animal models, the researchers showed that the highly conserved underlying mechanism of this symbiotic relationship is the production of reactive oxygen species (ROS), by a class of conserved enzymes called NADPH oxidases or Nox’es. When animal guts were colonized by Lactobacillus, ROS production caused cell growth in intestinal stem cells. In contrast, in germ-free animals ROS production was absent and resulted in suppressed growth of epithelial cells. Lead author Rheinallt M. Jones, commented: “Our data support the concept of commensal bacterial-induced generation of ROS as a transducer of bacterial signals into host cell signaling, thus establishing a mechanism for host/bacterial cross-talk.”
In addition, the study suggests that specific redox-mediated functions may contribute to the identification of further microbes with probiotic potential. The researchers also suggest that the primordial ancestral response to bacteria may well be the generation of ROS for signaling and microbicidal activities.
Symbiotic Lactobacilli Stimulate Gut Epithelial Proliferation via Noxmediated Generation of Reactive Oxygen Species
Rheinallt M. Jones, Liping Luo, Courtney S. Ardita, Arena N. Richardson, Young Man Kwon, Jeffrey W. Mercante, Ashfaqul Alam, Cymone L. Gates, Huixia Wu, Phillip A. Swanson, J. David Lambeth, Patricia W. Denning and Andrew S. Neish
Read the paper: http://www.nature.com/emboj/journal/vaop/ncurrent/full/emboj2013224a.html
Further information on The EMBO Journal is available at: http://www.nature.com/emboj/index.html
Media ContactsBarry Whyte
EMBO helps young scientists to advance their research, promote their international reputations and ensure their mobility. Courses, workshops, conferences and scientific journals disseminate the latest research and offer training in techniques to maintain high standards of excellence in research practice. EMBO helps to shape science and research policy by seeking input and feedback from our community and by following closely the trends in science in Europe.
Yvonne Kaul | EMBO Communications
'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS
New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
20.02.2018 | Life Sciences
20.02.2018 | Medical Engineering
20.02.2018 | Physics and Astronomy