"This is the first concise state-of-the-art review of stereological methods for lung morphometry that formulates practical guidelines for the use of advanced imaging techniques," said ATS past president, John Heffner, M.D. "The proposed standards ensure that the three dimensional window into the lung offered by advanced imaging techniques will provide the sharp and clear view necessary for the discovery of new respiratory cures."
The research policy statement was published in the February 15, 2010, issue of the American Journal of Respiratory and Critical Care Medicine.
Lung morphometry—the study of the structure of the lung on the whole-organ level—is of growing importance as new advanced imaging techniques provide investigators glimpses of previously inaccessible areas of lung architecture. The lung is composed of networks of increasingly tiny airways which, if laid out end-to-end, would extend for 1,500 miles, as well as tiny air sacs called alveoli which, if flattened, would have the surface area of a tennis court. However, these tremendously complex and intricate structures comprise only 10 to 15 percent of the volume of an inflated lung. The rest is air.
"When I look into a microscope at about 200 times magnification and observe a histological section of human lung tissue, I see kind of a network of thin bands that I suspect to represent the walls between airspaces, the empty-looking areas; and some of the network bands mysteriously have free ends," explained Ewald R. Weibel, M.D., D.Sc., who is senior author of the standards and professor emeritus at the Institute for Anatomy at the University of Berne in Switzerland.
New advanced lung imaging techniques offer genuine three-dimensional views of the lung, and because of their ready availability, these techniques provide investigators with tremendous opportunities to look into previously inaccessible crevasses of the whole lung and examine spatial displays of the relationship between tissues, cells, organelles, alveoli, airways and blood vessels. But if these imaging techniques are misapplied they can promote misinterpretations of findings and confuse investigators in the field. Correctly interpreting these images is of critical importance to understanding the exact structures of airways and alveoli.
"Stereology now tells us that the length of this two-dimensional contour of air spaces images (per unit area of section) is proportional to the surface area of the three-dimensional airspaces (per unit volume of lung tissue)," said Dr. Weibel. "This allows the alveolar surface, functionally the gas exchange surface, to be measured on thin sections with great precision. But because the relationship is a statistical one, there are strict rules that must be observed if such an indirect estimate of a three-dimensional surface area is to be accurate. These standards explain these rules."
"The standards also promote the quality of basic and translational lung research, particularly because the potential use of the methodological standards in the modern imaging modalities—such as high-resolution CT, MRI and PET—are outlined," Dr. Weibel continued. "If adopted by the research community, the standards should also improve the efficiency and accuracy of studies and, most importantly, make results obtained by different groups comparable, thus facilitating interdisciplinary and international collaboration."Link to original article: http://www.thoracic.org/newsroom/press-releases/resources/lung-structure-statement.pdf
Link to original podcast: http://www.thoracic.org/newsroom/press-releases/journal/podcast/lung-structure.mp3
Keely Savoie | EurekAlert!
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
24.05.2017 | Physics and Astronomy
24.05.2017 | Physics and Astronomy
24.05.2017 | Event News