Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Antidepressants linked with increased risks after surgery

30.04.2013
Bleeding, transfusion, readmission, death more likely after taking SSRIs

Selective serotonin reuptake inhibitors (SSRIs) – among the most widely prescribed antidepressant medications – are associated with increased risk of bleeding, transfusion, hospital readmission and death when taken around the time of surgery, according to an analysis led by researchers at UC San Francisco and Baystate Medical Center in Springfield, Mass.

The scientists looked at the medical records of more than 530,000 patients who underwent surgery at 375 U.S. hospitals between 2006 and 2008. Their results will be published on April 29 in JAMA Internal Medicine.

"There have been small studies that suggested there was a problem, but it has never been well-proven," said lead author Andrew D. Auerbach, MD, MPH, a UCSF professor of medicine. "With this huge data set, we feel confident in saying that SSRIs are associated with about a 10 percent increased risk for these adverse outcomes."

The study authors noted that patients on SSRIs are more likely to have conditions that in themselves increase surgical risk, such as obesity, chronic pulmonary disease and depression.

To address the question of whether these factors might have accounted for the differences in outcomes, they retrospectively matched patients who had taken SSRIs with patients who were not taking the drugs. After matching and controlling for variables such as age, gender, medical condition and depression, they found that patients on SSRIs still were at increased risk.

The scientists also looked at whether the increased risk could be accounted for by patients receiving SSRIs for the first time before surgery. "This was not the case," said Auerbach. "These drugs are almost never used acutely. They are prescribed for chronic conditions such as depression, almost always for long-term use."

The study was not designed to look at possible causes for the increased risk. However, noted Auerbach, SSRIs are known to interfere with the functioning of platelets – blood cells that play a crucial role in blood clotting. In turn, platelet dysfunction can lead to excess bleeding.

Auerbach cautioned that since the study was retrospective, "a prospective observational study, in which patients are randomly assigned to take SSRIs around the time of surgery, is still needed."

He said that while it would be premature to advise patients not to take SSRIs before surgery, "it's definitely worth discussing with your surgeon or primary care physician."

Co-authors of the paper are Eric Vittinghoff, PhD and Judith Maselli, MSPH, of UCSF; Penelope S. Pekow, PhD, of the University of Massachusetts Amherst and Baystate Medical Center; John Q. Young, MD, of UCSF; and senior author Peter K. Lindenauer, MD, MSc of Baystate Medical Center and Tufts University.

The study was supported by funds from the National Heart, Lung and Blood Institute (K24HL098372).

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.

Juliana Bunim | EurekAlert!
Further information:
http://www.ucsf.edu

More articles from Health and Medicine:

nachricht Antibiotic effective against drug-resistant bacteria in pediatric skin infections
17.02.2017 | University of California - San Diego

nachricht Tiny magnetic implant offers new drug delivery method
14.02.2017 | University of British Columbia

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>