Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Analyzing Tumor Cells in Blood Using Nanomagnets

16.07.2012
Siemens' researchers have been able to analyze blood cells by employing the same magnetic reading technology as is used for computer hard drives.

They have developed a prototype for the magnetic flow cytometry of blood. Blood is the most important source of diagnostic information for doctors tracking the success of therapy for a tumor or HIV. For their new process, the researchers are taking advantage of the GMR (giant magnetoresistance) effect, the discovery of which was the subject of the 2007 Nobel Prize in Physics.



In the field of medical diagnostics, an optical method of measurement for examining the characteristics of individual cells has existed for decades, remaining largely unchanged from the time it was developed. This method is known as flow cytometry, and can be used to identify specific cells, such as circulating tumor cells. Extracting cell data from whole blood, however, requires a time-consuming process. So the costs for traditional flow cytometry are too high for general clinical use or decentralized implementation, and growth in the market for this equipment has mostly been confined to the area of research.

But in the future, the new magnetic flow cytometry could offer a way of carrying out blood testing nearer to the patient (point-of-care), offering a method for specific cell detection in addition to a complete blood count. The scientists at Siemens Corporate Technology are employing GMR reading processes in combination with superparamagnetically marked cells.

Their demonstration model, which is not yet ready for the market, can quantitatively detect specifically marked analytes in whole blood, without requiring pre-conditioning of the sample, such as the lysis (destruction) of red blood cells. Specifically, the marking of these analyte blood cells is accomplished using antibodies, which have superparamagnetic nanoparticles (beads) hanging on them. A magnet then attracts the marked cells, so that they are separated out and, like pearls on a string, they are counted by the GMR sensor.

This process enables the quantitative identification of tumor cells, for example. Through this special experimental design the researchers get four bits of information for each individual cell that is measured. With this information they can determine the cell's diameter and the speed at which it is moving - information which allows them to make accurate conclusions about whether it is a tumor cell or not.

Recently, the researchers showed that miniaturization of this kind of measuring system would be possible. For demonstrating this possibility in his bachelor's thesis, a researcher won the Innovation Prize for Applied Research from Regensburg University of Applied Sciences.

Dr. Norbert Aschenbrenner | Siemens InnovationNews
Further information:
http://www.siemens.com/innovationnews

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>