They have developed a prototype for the magnetic flow cytometry of blood. Blood is the most important source of diagnostic information for doctors tracking the success of therapy for a tumor or HIV. For their new process, the researchers are taking advantage of the GMR (giant magnetoresistance) effect, the discovery of which was the subject of the 2007 Nobel Prize in Physics.
In the field of medical diagnostics, an optical method of measurement for examining the characteristics of individual cells has existed for decades, remaining largely unchanged from the time it was developed. This method is known as flow cytometry, and can be used to identify specific cells, such as circulating tumor cells. Extracting cell data from whole blood, however, requires a time-consuming process. So the costs for traditional flow cytometry are too high for general clinical use or decentralized implementation, and growth in the market for this equipment has mostly been confined to the area of research.
But in the future, the new magnetic flow cytometry could offer a way of carrying out blood testing nearer to the patient (point-of-care), offering a method for specific cell detection in addition to a complete blood count. The scientists at Siemens Corporate Technology are employing GMR reading processes in combination with superparamagnetically marked cells.
Their demonstration model, which is not yet ready for the market, can quantitatively detect specifically marked analytes in whole blood, without requiring pre-conditioning of the sample, such as the lysis (destruction) of red blood cells. Specifically, the marking of these analyte blood cells is accomplished using antibodies, which have superparamagnetic nanoparticles (beads) hanging on them. A magnet then attracts the marked cells, so that they are separated out and, like pearls on a string, they are counted by the GMR sensor.
This process enables the quantitative identification of tumor cells, for example. Through this special experimental design the researchers get four bits of information for each individual cell that is measured. With this information they can determine the cell's diameter and the speed at which it is moving - information which allows them to make accurate conclusions about whether it is a tumor cell or not.
Recently, the researchers showed that miniaturization of this kind of measuring system would be possible. For demonstrating this possibility in his bachelor's thesis, a researcher won the Innovation Prize for Applied Research from Regensburg University of Applied Sciences.
Dr. Norbert Aschenbrenner | Siemens InnovationNews
Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.
Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
25.05.2018 | Event News
02.05.2018 | Event News
13.04.2018 | Event News
25.05.2018 | Event News
25.05.2018 | Machine Engineering
25.05.2018 | Life Sciences