Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Allergies and wheezing illnesses in childhood may be determined in the womb

26.10.2010
A child’s chances of developing allergies or wheezing is related to how he or she grew at vital stages in the womb, according to scientists from the University of Southampton.

The new research, funded by the Medical Research Council (MRC) and the British Lung Foundation, and undertaken at Southampton General Hospital, reveals that fetuses which develop quickly in early pregnancy but falter later in pregnancy are likely to go on to develop allergies and asthma as children. Scientists believe this is due to changes in the development of their immune system and lungs.

A fetus that grows too slowly in the womb is also more likely to become an infant who wheezes with common colds, possibly as a result of narrower airways in its lungs.

“Childhood allergies and asthma have become an epidemic in developed countries over the last 50 years. This research shows that in order to combat this, we need to understand more about how babies develop in the womb,” comments Keith Godfrey, Professor of Epidemiology and Human Development at the University of Southampton and a consultant in dermatology at Southampton General Hospital.

“We already know that a baby’s growth in the womb has an important influence on susceptibility to obesity and heart disease in later life, but this research provides some of the most direct evidence yet that changes in how the baby’s immune system and lungs develops before birth can predispose them to some of the commonest childhood illnesses.”

For the research, published in the Journal Thorax, University of Southampton scientists at the MRC Epidemiology Unit based at Southampton General Hospital studied more than 1,500 three year-old children who were taking part in the Southampton Women’s Survey, the UK’s largest study of women and their offspring. The Survey has studied how a woman’s diet and lifestyle before and during pregnancy affects their baby’s growth in the womb, and is monitoring how these early life influences determine health and development during childhood.

The team discovered evidence of sensitivity to common allergens (atopy) in 27 per cent of children who had developed quickly in early pregnancy but faltered later in pregnancy, as compared with 4 per cent in those with a slow early growth trajectory and quicker growth in late pregnancy.

Professor Stephen Holgate, from the Medical Research Council, says: “Unravelling the complex interplay between immunity and disease, over the course of a person’s life, including before they are even born, is a core part of the MRC’s research strategy. Furthering our understanding of the body’s natural resilience is critical to developing new advances in the treatment of infectious diseases, autoimmune diseases and allergies.”

Ian Jarrold, Research Manager at the British Lung Foundation, says: “Children’s lung health can be complex so this research, funded by the British Lung Foundation, is a considerable step forward in understanding why some children are more likely to develop allergies and asthma.

“The most commonly reported long-term illnesses in children and babies are conditions of the respiratory system. Increasing our understanding of childhood lung conditions is vital for developing new ways of diagnosing and treating lung diseases earlier in life.”

Sophie Docker | EurekAlert!
Further information:
http://www.soton.ac.uk

More articles from Health and Medicine:

nachricht Vanishing capillaries
23.03.2017 | Technische Universität München

nachricht How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short

23.03.2017 | Life Sciences

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>