Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Age-related decline in sleep quality might be reversible

02.04.2014

Sleep is essential for human health. But with increasing age, many people experience a decline in sleep quality, which in turn reduces their quality of life. Scientists at the Max Planck Institute (MPI) for Biology of Ageing in Cologne have investigated the mechanisms by which ageing impairs sleep in the fruit fly. Their findings suggest that age-related sleep decline can be prevented and might even be reversible.

To uncover basic age-related sleep mechanisms, the Max Planck scientists studied the fruit fly Drosophila melanogaster, a classical model organism in ageing research. „Drosophila’s sleep has many features in common with that of humans, including the decline in quality“, says Luke Tain of the MPI for Biology of Ageing.


The fruit fly Drosophila melanogaster has a life expectancy of about eight weeks and is one of the model organisms scientists at the MPI for Biology of Ageing use to uncover what happ

Wolfgang Weiss for the Max Planck Institute for Biology of Ageing

„Like humans, flies sleep at night and are active during the day. We can observe when and how long flies sleep. We can also determine their sleep quality by measuring how often they wake. This allows us to study the effects of specific substances or other sleep-influencing factors such as age and genetic disposition.“

Ageing researchers Athanasios Metaxakis, Luke Tain, and Sebastian Grönke, in the department of MPI Director Linda Partridge, discovered that a reduced activity in the IIS signalling pathway leads to improved sleep quality at night and higher activity levels at day. A “signalling pathway” is a biological method of transferring information, and via those pathways, the cell can respond to external conditions like the state of food supply.

„In our study, we described the role of the IIS pathway in regulating sleep and activity through the neurotransmitters octopamine and dopamine“, explains Tain. „What makes this pathway so interesting to us is the fact that it is evolutionarily conserved. This means that its components and functions are similar in diverse species from simple organisms like fruit flies to mice and even humans. Furthermore, we were able to improve sleep quality by administering therapeutic agents.”

Moreover, the scientists found out that day activity and night sleep are regulated by two distinct signalling pathways, night sleep being mediated through TOR and dopaminergic signalling. Surprisingly, if TOR’s activity is acutely inhibited by treatment with the therapeutic agent Rapamycin, sleep quality improves even in old flies, suggesting that age-related sleep decline is not only preventable, but also reversible.

The scientists will follow up on their findings. Luke Tain: „Given the high evolutionarily conservation of IIS and TOR function, our results implicate potential therapeutic targets to improve sleep quality in humans. This would be our longer-term goal. The next step however, is to find out whether these mechanisms also work in higher animals like mice.“

Original publication:
Lowered Insulin Signalling Ameliorates Age-Related Sleep Fragmentation in Drosophila. Athanasios Metaxakis, Luke S. Tain, Sebastian Grönke, Oliver Hendrich, Yvonne Hinze, Ulrike Birras, and Linda Partridge. PLOS Biology, April 1, 2014.

Weitere Informationen:

http://www.age.mpg.de

Sabine Dzuck | Max-Planck-Institut

Further reports about: Drosophila IIS MPI Max-Planck-Institut Partridge TOR activity age-related decline flies humans pathway signalling sleep

More articles from Health and Medicine:

nachricht Loyola study reveals how HIV enters cell nucleus
23.06.2016 | Loyola University Health System

nachricht Updated DIfE – GERMAN DIABETES RISK TEST Optimized for Mobile Devices
22.06.2016 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Flexible OLED applications arrive

R2D2, a joint project to analyze and development high-TRL processes and technologies for manufacture of flexible organic light-emitting diodes (OLEDs) funded by the German Federal Ministry of Education and Research (BMBF) has been successfully completed.

In contrast to point light sources like LEDs made of inorganic semiconductor crystals, organic light-emitting diodes (OLEDs) are light-emitting surfaces. Their...

Im Focus: Unexpected flexibility found in odorant molecules

High resolution rotational spectroscopy reveals an unprecedented number of conformations of an odorant molecule – a new world record!

In a recent publication in the journal Physical Chemistry Chemical Physics, researchers from the Max Planck Institute for the Structure and Dynamics of Matter...

Im Focus: 3-D printing produces cartilage from strands of bioink

Strands of cow cartilage substitute for ink in a 3D bioprinting process that may one day create cartilage patches for worn out joints, according to a team of engineers. "Our goal is to create tissue that can be used to replace large amounts of worn out tissue or design patches," said Ibrahim T. Ozbolat, associate professor of engineering science and mechanics. "Those who have osteoarthritis in their joints suffer a lot. We need a new alternative treatment for this."

Cartilage is a good tissue to target for scale-up bioprinting because it is made up of only one cell type and has no blood vessels within the tissue. It is...

Im Focus: First experimental quantum simulation of particle physics phenomena

Physicists in Innsbruck have realized the first quantum simulation of lattice gauge theories, building a bridge between high-energy theory and atomic physics. In the journal Nature, Rainer Blatt‘s and Peter Zoller’s research teams describe how they simulated the creation of elementary particle pairs out of the vacuum by using a quantum computer.

Elementary particles are the fundamental buildings blocks of matter, and their properties are described by the Standard Model of particle physics. The...

Im Focus: Is There Life On Mars?

Survivalist back from Space - 18 months on the outer skin of the ISS

A year and a half on the outer wall of the International Space Station ISS in altitude of 400 kilometers is a real challenge. Whether a primordial bacterium...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Conference ‘GEO BON’ Wants to Close Knowledge Gaps in Global Biodiversity

28.06.2016 | Event News

ERES 2016: The largest conference in the European real estate industry

09.06.2016 | Event News

Networking 4.0: International Laser Technology Congress AKL’16 Shows New Ways of Cooperations

24.05.2016 | Event News

 
Latest News

Rotating ring of complex organic molecules discovered around newborn star

28.06.2016 | Physics and Astronomy

Unidentified spectra detector

28.06.2016 | Life Sciences

Clandestine black hole may represent new population

28.06.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>