Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

An advance toward blood transfusions that require no typing

10.03.2011
Scientists are reporting an "important step" toward development of a universal blood product that would eliminate the need to "type" blood to match donor and recipient before transfusions. A report on the "immunocamouflage" technique, which hides blood cells from antibodies that could trigger a potentially fatal immune reaction that occurs when blood types do not match, appears in the ACS journal, Biomacromolecules.

Maryam Tabrizian and colleagues note that blood transfusions require a correct match between a donor and the recipient's blood. This can be a tricky proposition given that there are 29 different red blood cells types, including the familiar ABO and Rh types. The wrong blood type can provoke serious immune reactions that result in organ failure or death, so scientists have long sought a way to create an all-purpose red blood cell for transfusions that doesn't rely on costly blood typing or donations of a specific blood type.

To develop this "universal" red blood cell, the scientists discovered a way to encase living, individual red blood cells within a multilayered polymer shell. The shell serves as a cloaking device, they found, making the cell invisible to a person's immune system and able to evade detection and rejection. Oxygen can still penetrate the polymer shell, however, so the red blood cells can carry on their main business of supplying oxygen to the body. "The results of this study mark an important step toward the production of universal RBCs," the study states.

The authors acknowledge funding from the Fonds de la Recherche en Santé du Québec, the Natural Sciences and Engineering Council of Canada, the Canadian Institutes for Health Research and FQRNT-Centre for Biorecognition and Biosensors.

ARTICLE FOR IMMEDIATE RELEASE "Investigation of Layer-by-Layer Assembly of Polyelectrolytes on Fully Functional Human Red Blood Cells in Suspension for Attenuated Immune Response"

CONTACT:
Maryam Tabrizian, Ph.D.
Department of Biomedical Engineering and Faculty of Dentistry
McGill University
Montreal, Canada
Phone: (514) 398-8129
Email: maryam.tabrizian@mcgill.ca

Michael Bernstein | EurekAlert!
Further information:
http://www.acs.org

More articles from Health and Medicine:

nachricht Penn studies find promise for innovations in liquid biopsies
30.03.2017 | University of Pennsylvania School of Medicine

nachricht 'On-off switch' brings researchers a step closer to potential HIV vaccine
30.03.2017 | University of Nebraska-Lincoln

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

'On-off switch' brings researchers a step closer to potential HIV vaccine

30.03.2017 | Health and Medicine

Penn studies find promise for innovations in liquid biopsies

30.03.2017 | Health and Medicine

An LED-based device for imaging radiation induced skin damage

30.03.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>