Olfactory dysfunction can arise from a variety of causes and can profoundly influence a patient's quality of life. The sense of smell determines the flavor of foods and beverages and also serves as an early warning system for the detection of environmental hazards, such as spoiled food, leaking natural gas, smoke, or airborne pollutants. The loss or distortions of smell sensation can adversely influence food preference, food intake, and appetite.
Approximately 2 million Americans experience some type of olfactory dysfunction. One of the most frequent causes of loss of smell in adults is an upper respiratory tract infection (URI). Patients usually complain of smell loss following a viral URI. The smell loss is most commonly partial, and reversible. However, occasionally patients may also present with parosmia (a distortion of the sense of smell), phantosmia (smelling things that aren't there), or permanent damage of the olfactory system.
To date, there is no validated pharmacotherapy for PVOD, but attempts have been made to establish a standardized treatment. In the literature, systemic and topical steroids as well as vitamin B supplements, caroverine, alpha lipoic acid, and other drugs were used to treat patients. The researchers point out that in addition to these treatments, complementary and alternative medicines are currently being employed by many patients on their own, and that exploration into their usefulness by traditional Western medicine should be validated.
In the current study, 15 patients presenting to an outpatient clinic with PVOD were treated by TCA in 10 weekly 30-minute sessions. Subjective olfactometry was performed using the Sniffin' Sticks test set. Treatment success was defined as an increase of at least six points in the sticks test scores. The effects of TCA were compared to matched pairs of people suffering from PVOD who had been treated with vitamin B complex. Eight patients treated with TCA improved olfactory function, compared with two treated with vitamin B complex.
The authors acknowledge that their study is limited by its size, and that further studies should be conducted in a larger population. However, the authors write "…the observed high response rate of about 50 percent under TCA was superior to that of vitamin B complex or that of spontaneous remission, and offers a possible new therapeutic regimen in postviral dysosmia."
Otolaryngology – Head and Neck Surgery is the official scientific journal of the American Academy of Otolaryngology – Head and Neck Surgery Foundation (AAO-HNSF). The study's authors are Julia Vent, MD, PhD; Djin-Wue Wang, MD; and Michael Damm, MD.
Reporters who wish to obtain a copy of the article should contact Jessica Mikulski at 1-703-535-3762, or firstname.lastname@example.org.
About the AAO-HNS
The American Academy of Otolaryngology – Head and Neck Surgery (www.entnet.org), one of the oldest medical associations in the nation, represents nearly 12,000 physicians and allied health professionals who specialize in the diagnosis and treatment of disorders of the ears, nose, throat, and related structures of the head and neck. The Academy serves its members by facilitating the advancement of the science and art of medicine related to otolaryngology and by representing the specialty in governmental and socioeconomic issues. The organization's vision: "Empowering otolaryngologist-head and neck surgeons to deliver the best patient care."
Jessica Mikulski | EurekAlert!
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences