Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Acne-treating antibiotic cuts catheter infections in dialysis patients

19.08.2011
Combination of antibiotic plus chemical prevents infections that cause illness and death

Antibiotics can help ward off serious bacterial infections in kidney disease patients who use tubes called catheters for their dialysis treatments. But if antibiotics are used too often, "super bugs" may crop up that are resistant to the drugs.

A new randomized controlled clinical trial has shown that using an antibiotic that is not usually used to treat other serious infections may be a safe way to prevent bacterial infections in dialysis patients. The study, which included approximately 200 dialysis patients,was conducted by Rodrigo Peixoto Campos, MD (Pontifícia Universidade Católica do Paraná, in Curitiba, Brazil) and colleagues, and appears in an upcoming issue of the Journal of the American Society Nephrology (JASN), a publication of the American Society of Nephrology.

Between dialysis treatments, a catheter is "locked" to prevent blood clots from forming within the device. A lock is usually made by injecting the blood thinner heparin into the catheter. In this study, researchers compared heparin use with a solution made up of the antibiotic minocycline and the chemical EDTA. Minocycline is routinely used only to treat acne, and EDTA improves the action of antibiotics, fights fungal infections, and prevents blood clots. Half of patients in the study had catheter locks containing this combination while the other half had catheter locks containing only heparin.

Among the major findings:

Patients were less likely to get a bacterial infection with minocycline-EDTA locks compared to heparin locks.

During a 90 day period, bacterial infections developed in the catheters of 19 patients in the heparin group compared with only five patients in the minocycline-EDTA group.

The catheters in the two groups functioned similarly well.

"When a dialysis clinic cannot achieve lower rates of catheter-related bacterial infections with routine catheter care protocols, the use of a catheter lock solution of minocycline-EDTA may be the next step to reduce this major complication, without the apprehension of developing bacterial resistance to systemic antibiotics," said Dr. Campos.

Study co-authors include Marcelo Mazza do Nascimento, MD, PhD (Hospital Universitário Evangélico de Curitiba, in Curitiba, Brazil); Domingos Candiota Chula, MD (Clínica de Doenças Renais do Novo Mundo, in Curitiba, Brazil); and Miguel Carlos Riella, MD, PhD, FACP (Pontifícia Universidade Católica do Paraná and Hospital Universitário Evangélico de Curitiba, in Curitiba, Brazil).

Disclosures: The authors reported no financial disclosures.

The article, entitled "Hemodialysis Catheter-Related Bacteremia Prevention Using a Locking Solution of Minocycline-EDTA," will appear online at http://jasn.asnjournals.org/ doi #10.1681/ASN.2010121306

The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Founded in 1966, and with more than 12,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.

Adrienne lea | EurekAlert!
Further information:
http://www.asn-online.org

More articles from Health and Medicine:

nachricht World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern

nachricht Therapy of preterm birth in sight?
19.07.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>